A Study to Understand Why Laying Down May Influence High Blood Pressure in Patient's with a Disease that Causes Problems with the Autonomic Nervous System

Overview

  • Study type

    Interventional
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 12-002101
    Sponsor Protocol Number: 12-002101

About this study

The purpose of this research study is to better understand why patients with a disease that causes problems with the autonomic nervous system often have high blood pressure when they lie down. We hope that if we learn more about the cause for this problem, we will be able to treat the problem better in the future.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

MSA and PAF:

  • Males or females age 18-75 years
  • Clinically diagnosed as probable MSA or probable PAF based on established research criteria
  • Orthostatic BP drop ³30 mmHg systolic and/or ³15 mmHg diastolic within 3 minutes of head-up tilt.
  • Supine BP ³ 160 mmHg systolic and/or 95 mmHg diastolic

Control Subjects:

  • Males or females age 18-75 years
  • Normal autonomic reflex screen

Exclusion Criteria:

  • Pregnant/lactating females – a pregnancy test will be required for women of childbearing potential.
  • The presence of failure of organ systems or systemic illness that can affect autonomic function.
  • Concomitant therapy with anticholinergic, alpha- and beta-adrenergic antagonists or other medication which could interfere with testing of autonomic function.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Wolfgang Singer, M.D.

Open for enrollment

Contact information:

Anita Zeller CCRP

(507)284-2090

zeller.anita@mayo.edu