A Study to Determine How Corneal Transparency is Affected in Fuchs Dystrophy

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 12-004579
    Sponsor Protocol Number: 12-004579

About this study

The purpose of this study is to determine how corneal transparency is affected in Fuchs dystrophy, and if a measure of corneal transparency (haze) can help grade the severity of the disease.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

Fuchs group

  1. Presence of central or paracentral corneal guttae
  2. Any age (expected range will be 40-90)
  3. Any sex or race

Normal group

  1. Absence of central or paracentral corneal guttae
  2. Ages 51-80 (to match the predominant age of subjects with Fuchs dystrophy)
  3. Any sex or race

Exclusion Criteria: 

  1. Any corneal disease (except Fuchs dystrophy in the Fuchs group)
  2. Previous ocular surgery (except for cataract surgery with posterior chamber intraocular lens in the Fuchs dystrophy group)
  3. Use of topical ocular medications, expect artificial tears
  4. Glaucoma or ocular hypertension
  5. Systemic diseases known to affect the cornea, e.g. diabetes

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Sanjay Patel, M.D.

Closed for enrollment

Contact information:

Diane Vogen

(507)293-0621

Vogen.Diane2@mayo.edu

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CLS-20314162

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