A Study of Sex-Specific Repair Changes in the Brain Following a Concussion

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Scottsdale/Phoenix, Arizona: 16-009079
    Sponsor Protocol Number: 16-009079

About this study

The purpose of this study is evaluate changes in male and female athletes’ brains following concussion injury and recovery, and to see whether female athletes demonstrate a different pattern of recovery compared to male athletes.

 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • Healthy controls
    • Age 16-55
    • Males or females
  • Patients with concussion
    • Age 16-55
    • Males or females
    • Classification of concussion using the Ohio State University TBI identification method

Exclusion Criteria

  • Healthy controls
    • History of neurological disorder
    • Classification of a concussion using the Ohio State University TBI identification method
    • History of migraine or other headache disorder
      • Tension-type headache on 3 or fewer days per month is allowed
    • Gross anatomical abnormalities on T1-weighted imaging identified during routine visual inspection
    • Contra-indications to MR imaging
      • e.g Severe claustrophobia
      • e.g Metal in the body
    • Pregnancy
  • Patients with concussion
    • History of neurological disorder as seen clinically on MRI
    • Gross anatomical abnormalities on T1-weigthed imaging identified during routine visual inspection
    • Contra-indications to MR imaging
      • e.g. Severe claustrophobia 
      • e.g. Metal in the body
    • Pregnancy

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

Catherine Chong, Ph.D.

Open for enrollment

Contact information:

Saran Vaughn

(480)342-6487

Vaughn.Saran@mayo.edu