A Study of Gene and Protein Expression Profiles in Acute versus Chronic Elbow Contractures

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 08-003403
    Sponsor Protocol Number: 08-003403

About this study

The purpose of this study is to determine a comprehensive gene expression profile of patients with a high likelihood of developing an elbow contracture (acute) versus those with established elbow contractures (chronic).  Similarly, the Mayo Proteomics Research Center will be used to determine a comprehensive protein expression profile of patients with a high likelihood of developing an elbow contracture (acute) versus those with established elbow contractures (chronic).

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • Has acute trauma to the elbow requiring operative intervention
    • Either a fracture or dislocation of the elbow 
    • Operated on within 2 weeks of the injury 
    • Does not fulfill any of the exclusion criteria
  • Has established elbow contractures undergoing operative intervention
    • Has high-grade motion loss or frank ankylosis as determined by the consultant surgeon 
    • Does not fulfill any of the exclusion criteria
  • No elbow fibrosis undergiong operative intervention
    • Has normal elbow range of motion 
    • Having excision of the elbow capsule for non-fibrotic pathologies 
  • Does not fulfill any of the exclusion criteria

Exclusion Criteria

  • Age less than 15 years
  • History of infection in operative extremity
  • History of malignancy in operative extremity
  • Presence of a condition interfering with the ability to provide informed consent

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Mark Morrey, M.D.

Contact us for the latest status

Contact information:

Jessica Stutzman

(507)266-1227

Stutzman.Jessica@mayo.edu