Multi-phase Dual Energy for Quantitative and Radiologic Evaluation of Chronic Liver Disease

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 14-002169
    Sponsor Protocol Number: 14-002169

About this study

The purpose of this study is to assess the combined impact of post-processing methods that quantify potential biomarkers of chronic liver disease (AEF, fECS) and that improve iodine signal (vMono+) on detecting liver fibrosis and hepatic masses or esophageal varices, in comparison to routine contrast-enhanced liver CT.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Known or suspected chronic liver disease with or without hepatocellular carcinoma.
  • Informed consent to research contrast-enhanced, dual energy CT and unenhanced MR scan with elatography.
  • Serum creatine, bilirubin and INR ordered for clinical purposes.
  • A negative pregnancy test is required, if the subject is a female of child bearing age

Exclusion Criteria: 

  • Any contraindication for MR imaging (MRI) including pacemakers, cochlear implants, and certain spinal stimulation devices.
  • Insufficient MR image quality for quantitative analysis.
  • A female subject with a positive pregnancy test

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Joel Fletcher, M.D.

Open for enrollment

Contact information:

Joel Fletcher M.D.

(507)284-3207

.
CLS-20309521

Mayo Clinic Footer