Patients with Inflammatory Bowel Disease (IBD) are at Increased Risk for Colorectal Cancer and Early Dysplasia

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 14-005543
    Sponsor Protocol Number: 14-005543

About this study

The purpose of the study is to:

  • Map and compare the neoplasia-associated epigenetic field in IBD-CRN, sporadic CRN and controls.  
  • Measure sensitivity of DNA methylation for the detection of synchronous IBD-CRN as a complement or alternative to histologic diagnosis of dysplasia on random biopsies. 
  • Measure the density and types of lymphocytes infiltrating IBD-CRN tumors, sporadic tumors and the epigenetic field. 

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Subject population:  Patients with chronic colitis (ulcerative colitis or Crohn’s colitis) who have undergone surgery to treat medically refractory disease or disease complications, including advanced pre-cancer or cancer of the colorectum.

 

Inclusion Criteria:

Patients will be adults having surgery at Mayo Clinic with chronic inflammatory bowel disease of the colon. 

 

Exclusion Criteria: 

Pre-operative chemotherapy or radiation;

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

John Kisiel, M.D.

Open for enrollment

Contact information:

John Kisiel M.D.

(507)284-0959

Kisiel.John@mayo.edu

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CLS-20308370

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