Effect of Spasticity on Motor Neuron Properties
Overview
Tab Title Description
Study type
ObservationalDescribes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
Study IDs
Site IRB
- Rochester, Minnesota: 15-006759
Sponsor Protocol Number: 15-006759
About this study
The purpose of this study is to compare motor neuron properties in adolescents and adults with and without spastic cerebral palsy (sCP).
Participation eligibility
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.
Inclusion Criteria:
- Individuals with sCP:
- Age 15 or older with a known diagnosis of cerebral palsy and spasticity.
- Individuals without sCP:
Exclusion Criteria:
- Individuals with sCP:
- Botulinum toxin injection to the muscle of interest in the past 3 months
- A history of phenol neurolysis to the fibular nerve or sciatic nerve
- Active titration of oral baclofen or anti-epileptic medications
- History of a selective dorsal rhizotomy
- Presence of a baclofen pump
- Having any other neuromuscular disorder
- Individuals without sCP:
- Presence or history of a peripheral or compressive neuropathy
- Myopathy
- Injury to the nerve or muscle of interest
- Abnormality of the central nervous system (stroke, traumatic brain injury (with presence of spasticity or movement difficulties), spinal cord injury, neurodegenerative condition, or central nervous system tumor)
- Any other neuromuscular disorder
Participating Mayo Clinic locations
Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.
| Mayo Clinic Location |
Status |
|
Rochester, Minn.
Mayo Clinic principal investigator Joline Brandenburg, M.D. |
Closed for enrollment |
|
More information
Publications
Publications are currently not available