A Study to Assess if Contrast-Enhanced Ultrasound Positively Influences the Selection of Biopsy Sites When Evaluating Transplant Kidneys

Overview

  • Study type

    Interventional
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Scottsdale/Phoenix, Arizona: 14-009240
    NCT ID: NCT02625428
    Sponsor Protocol Number: 14-009240

About this study

The purpose of this pilot study is to investigate whether contrast-enhanced ultrasound (CEUS) may help evaluate segmental differences in renal perfusion better than doppler ultrasound and thus help direct a biopsy to the most abnormal part of the renal cortex.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria

  • Ability to provide informed consent
  • Male and female >18 years
  • Patients undergoing renal transplant ultrasound-guided percutaneous biopsy within 14 months post transplant including patients undergoing biopsy to evaluate a recent rise in serum creatinine, (so called "for cause" biopsies) and patients undergoing routine protocol (surveillance) biopsies without other evidence of renal dysfunction

 

Exclusion Criteria

  • Pregnant women or women who are nursing an infant are not able to participate in this study
  • Known patent foramen ovale (PFO)
  • Significant heart disease

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Scottsdale/Phoenix, Ariz.

Mayo Clinic principal investigator

J Kriegshauser, M.D.

Open for enrollment

Contact information:

Sandra Kavuma

(480)342-0349

Kavuma.Sandra@mayo.edu