Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.
Study type: Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Rochester, Minnesota: 13-004966
NCT ID: NCT01956929
Sponsor Protocol Number: 13-004966
About this study
This study is being done to understand metformin's mechanisms of action regarding glucose production, protein metabolism, and mitochondrial function.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.
See eligibility criteria
- 35-65 years of age
- Fasting blood glucose >100 mg/dl
- BMI 27-36 kg/m2
- Waist Circumference: Men ≥ 104 cm; women ≥ 88 cm
- If previously on anti-diabetic medication, should be off for at least 1 month
- Active use of hypoglycemic agents (< 1 month)
- Renal failure, creatinine ≥ 1.5 mg/dL in men or ≥ 1.4 mg/dL in women
- Alanine aminotransferase levels exceed 135 IU/L or aspartate aminotransferase levels exceed 129 IU/L (3 x the upper limit of normal)
- Congestive Heart Failure (EF < 40 %)
- Active coronary artery disease
- Recent (less than 6 weeks) or planned imaging study requiring IV contrast
- Participation in structured exercise (> 2 hr per week)
- Recent change in dietary habits or weight
- Tobacco use
- Use of systemic glucocorticoids
- Anti-coagulant therapy (warfarin/heparin)
- Pregnancy or breastfeeding
- Alcohol consumption greater than 2 drinks/day
- Uncontrolled Hypothyroidism, abnormal thyroid stimulating hormone levels
- Metformin Allergy
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.