Genomics of Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC)

Overview

  • Study type

    Observational
  • Study IDs

  • Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
  • Site IRB
    • Rochester, Minnesota: 670-02
    NCT ID: NCT01161953, NCT01161992
    Sponsor Protocol Number: 670-02

About this study

Chronic cholestatic liver diseases, such as Primary Biliary Cirrhosis (PBC) and Primary Sclerosing Cholangitis (PSC), are progressive liver disorders of unknown cause. Current evidence suggests that genes, the genetic material we inherit from our parents, in combination with environmental factors, likely play an important role in the development of PBC or PSC.

This study is being done to investigate whether genes make people more likely to develop PBC or PSC. Discovery of these genes will help us to understand better how PBC or PSC develops and subsequently, to apply new approaches for its prevention, diagnosis, and treatment.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Men, Women, and Children between the ages of 5-90 with a history of PSC.
  • Men and women between the ages of 18-90 who have a history of PBC.
  • PBC or PSC patients who have undergone a liver transplant are eligible.
  • Family members (1st degree relatives) of enrolled PBC or PSC patients are eligible.

Exclusion Criteria:

  • Individuals with no history of PBC or PSC or those unable to provide consent.

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Konstantinos Lazaridis, M.D.

Open for enrollment

Contact information:

Erik Schlicht CCRP

(507)284-4312

Schlicht.Erik@mayo.edu

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CLS-20132731

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