Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults

  • Study type:

    Interventional What is this?

    Describes the nature of a clinical study. Types include:

    • Observational study — observes people and measures outcomes without affecting results.
    • Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
    • Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.

Study IDs

  • Site IRB:

    • Rochester, Minnesota: 10-005853
  • NCT ID:

    NCT01477164
  • Sponsor Protocol Number:

    10-005853

About this study

Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine the ability for endurance, resistance, or a combination of exercise training to remove older-damaged proteins and make newer-functional muscle proteins in groups of younger and older people. The investigators will particularly study protein that are involved with energy production (mitochondrial proteins) and force production (contractile proteins).

Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger people.

Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile and mitochondrial proteins in younger and older people.

Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of contractile proteins in younger and older people.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.

See eligibility criteria

Inclusion Criteria:

  • Healthy
  • 18 to 30 years or 65 to 80 years old
  • Male and female

Exclusion Criteria:

  • Regular exercise program
  • Smoking
  • Metabolic disease (diabetes, cardiovascular disease, cancer, thyroid disorders)
  • Pregnancy
  • Inability to exercise
  • Overweight or obesity
  • Drugs known to impair metabolic function (statin, beta-blocker, anti-inflammatory)
  • Allergies to lidocaine

Participating Mayo Clinic locations

Study statuses change often. Please contact us for help.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

K Nair, M.D., Ph.D.

Closed for enrollment

Matthew Robinson Ph.D.

(507)255-9610

Robinson.Matthew@mayo.edu