Plasma Triglyceride Extraction by the Muscle
Study type: Interventional What is this?
Describes the nature of a clinical study. Types include:
- Observational study — observes people and measures outcomes without affecting results.
- Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
- Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best.
- Scottsdale/Phoenix, Arizona: 12-005173
NCT ID: NCT01860911
Sponsor Protocol Number: 12-005173
About this study
Increased accumulation of fat into the muscles is associated with what is called insulin-resistant state, which is a pre-diabetic state. The purpose of this research is to find out how fat circulating in the blood following fat consumption is taken up by the muscles in healthy people as well as people that are insulin-resistant. The investigators are specifically interested in how a hormone called insulin is involved in this process. Findings from this research will contribute to our understanding of why insulin-resistant people have increased accumulation of fat in their muscles, and ultimately help to design appropriate interventions to prevent type 2 Diabetes.
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. If you need assistance understanding the eligibility criteria, please contact the study team.
See eligibility criteria
- Body mass index (BMI): < 25 kg/m2 or > 30 kg/m2;
- Insulin sensitivity index (ISI): insulin-sensitive ISI ≥ 7, insulin-resistant ISI ≤ 5.
- Medication or supplements known to affect either endothelial function or lipid metabolism (i.e. arginine, protein, fish oil)
- Acute illness
- Uncontrolled metabolic disease, including liver or renal disease
- Atrial fibrillation, history of syncope, limiting or unstable angina, congestive heart failure, known or suspected right-to-left, bi-directional or transient right-to-left cardiac shunts
- Cardiac pacemaker or other medical device implanted in the body
- Pulmonary hypertension or other unstable cardiopulmonary conditions
- ECG documented abnormalities or valvular disease
- Low hemoglobin or hematocrit (i.e., lower than accepted laboratory values)
- History of hypertension or elevated blood pressure (systolic, >140 mmHg or a diastolic, >95 mmHg)
- History of hyperlipidemia or plasma triglyceride concentration >200 mg/dl
- Diagnosed diabetes, or 2-h plasma glucose >200 mg/dl during an oral glucose tolerance test
- Current participation in a weight-loss regimen, including extreme dietary practices
- Use of anabolic steroids or corticosteroids (within 3 months)
Participating Mayo Clinic locations
Study statuses change often. Please contact us for help.
|Mayo Clinic Location
Mayo Clinic principal investigator
Lori Roust, M.D.
Open for enrollment
Jennifer Early B.S.N., R.N.