HBRN: Immune Regulation and Costimulation in Natural History and Therapeutic Outcome of Chronic Hepatitis B

Location:

Rochester, Minn.

Trial status:
Open for Enrollment
Why is this study being done?

Aim 1. Therapeutic HBV suppression will enhance antiviral immune effector responses and reduce immune inhibitory factors in participants with chronic hepatitis B. This study will also examine if antiviral therapy has a durable effect in host immune phenotype and define the immunological effect of interferon-alpha (IFNα) therapy in chronic HBV participants. Aim 2. Antiviral immune effector and regulatory responses before, during and/or after therapy can predict long term therapeutic response.

Who is eligible to participate?

Inclusion Criteria: - Exclusion Criteria: - Children under 18 years of age, participants with anemia - Anemia with Hgb<10 or Hct<30 and active medical conditions such as congestive heart failure or chronic lung disease requiring oxygen, active coronary artery disease with unstable angina, sepsis and renal failure - Participants with significant medical conditions

Last updated:
6/21/2013
NCT ID:
NCT01796457
IRB Number:
11-000706