Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis

Location:

Rochester, Minn.

Trial status:
Open for Enrollment
Why is this study being done?

The overall goal of this project is to determine whether well-established environmental and genetic risk factors for adult onset MS play an important role in susceptibility to pediatric-onset MS. Our study design is based on the hypothesis that genetic influences, specifically variation at HLA-DRB1 and other confirmed non-MHC MS loci, as well as environmental exposures including EBV infection and tobacco smoke, contribute to disease risk. In addition, we will also examine the relationship between serum levels of 25(OH) vitamin D3 and prior vitamin D status, and risk for pediatric onset MS. Finally, we will investigate whether specific G x E, and other multivariable relationships influencing risk exist for pediatric-onset MS. There are 12 collaborating sites other than UCSF that will enroll cases and controls for this study.

Who is eligible to participate?

Case Inclusion Criteria: - Patients with relapsing-remitting MS or clinically isolated symptoms (CIS) who experience disease onset before 18. - Children whose MRI shows at least two silent abnormal T2-bright white matter foci (one must be in the brain) and who have abnormal cerebrospinal fluid satisfy criteria for dissemination in space. - MS onset occurred less than 2 years prior to enrollment in study. Case Exclusion Criteria: - Patients with relapsing-remitting MS or clinically isolated symptoms (CIS) who experience disease onset at 18 years or older. - Children whose MRI does not show at least two silent abnormal T2-bright white matter foci (one must be in the brain) and who have abnormal cerebrospinal fluid satisfy criteria for dissemination in space. - MS onset occurred more than 2 years prior to enrollment in study. Control Inclusion Criteria: - Healthy patients that do not have MS or another autoimmune disease (except asthma or eczema). - Are 19 years or younger. Control Exclusion Criteria: - Has an immediate, biological family member (parent/sibling) that has been diagnosed with multiple sclerosis. - Has a chronic neurological condition with major disability (not including migraine, uncontrolled seizures and mild learning disabilities such as ADD or ADHD).

Last updated:
9/23/2013
NCT ID:
NCT01396343