Image Gallery

  • Polycystins and calcineurin colocalize in sensory cilia of male worm tail neurons.
    Polycystins and calcineurin colocalize

    Polycystins and calcineurin colocalize in sensory cilia of male worm tail neurons.

  • Pronephric ducts in zebrafish labeled with a Pax 2 antisense riboprobe.
    Pronephric ducts

    Pronephric ducts in zebrafish labeled with a Pax 2 antisense riboprobe.

  • Interactive image analysis of cyst volume using Meta-Morph software and a colored threshold to separate cystic from non-cystic renal tissue.
    Interactive image analysis of cyst volume

    Interactive image analysis of cyst volume using Meta-Morph software and a colored threshold to separate cystic from non-cystic renal tissue.

  • Picrosirius red stain to quantify renal fibrosis.
    Picrosirius red stain

    Picrosirius red stain to quantify renal fibrosis.

  • Interactive image analysis of cyst volume using Meta-Morph software and a colored threshold to separate cystic from non-cystic renal tissue.
    Interactive image analysis of cyst volume

    Interactive image analysis of cyst volume using Meta-Morph software and a colored threshold to separate cystic from non-cystic renal tissue.

  • Picrosirius red stain to quantify hepatic fibrosis.
    Picrosirius red stain

    Picrosirius red stain to quantify hepatic fibrosis.

  • Kidney sections from 24 days old Pkd1f/-:ERCre mice
    Kidney sections

    Kidney sections from 24 days old Pkd1f/-:ERCre mice treated with tamoxifen at P1-P2, stained with hematoxylin and eosin (A); F13 antibodies (B), Tamm-Horsfall protein (C) or lysozyme (D); and with lotus tetragonolobus (E) or dolichos biflorus (F) lectins. Most cysts stain with distal nephron (C) or collecting duct (D, F) markers, but not with proximal tubule markers (B, E)

  • Immunohistochemical staining of Pkd2-/WS25 mouse kidney
    Immunohistochemical staining

    Immunohistochemical staining of Pkd2-/WS25 mouse kidney (A-B, collecting duct stains with Dolichos biflorus lectin or F13 antibodies; C, thick ascending limb stain with Tamm-Horsfall protein antibodies; proximal tubule stain with lysozyme antibodies).

  • Polycystic kidney and liver, intracranial aneurysm and cystic pancreas in a murine model of ADPKD.
    Murine model

    Polycystic kidney and liver, intracranial aneurysm and cystic pancreas in a murine model of ADPKD.

  • Intrahepatic biliary trees from 3 month old wild type and PCK rats.
    Intrahepatic biliary trees

    Intrahepatic biliary trees from 3 month old wild type and PCK rats.

  • Bile ducts of normal and PCK rats grown in 3-D culture after 1 (A, D), 3 (B, E) and 5 (C, F) days.
    Bile ducts

    Bile ducts of normal and PCK rats grown in 3-D culture after 1 (A, D), 3 (B, E) and 5 (C, F) days.

  • MDCK cysts grown in a collagen matrix.
    MDCK cysts

    MDCK cysts grown in a collagen matrix.

  • Colocalization of acetylated a-tubulin (red) and fibrocystin in primary cilia of confluent MDCK cells.
    Colocalization of acetylated a-tubulin

    Colocalization of acetylated a-tubulin (red) and fibrocystin in primary cilia of confluent MDCK cells.

  • Exosomes adhering to a primary cilium.
    Exosomes

    Exosomes adhering to a primary cilium.