Translational Polycystic Kidney Disease (PKD) Center

Moderately advanced autosomal dominant polycystic kidney disease.

End-stage autosomal dominant polycystic kidney disease.

Coronal MR and CT images of a patient with typical ADPKD and another with markedly asymmetric liver involvement.

Wide spectrum of disease severity and extrarenal manifestations (intracranial aneurysms, thoracic aortic dissection, retinal artery and vein occlusions, pericardial effusion, pancreatic cysts and intrapapillary mucinous neoplasm, seminal vesicle cysts, arachnoid cyst, dural diverticulum, colonic and duodenal diverticula).

Stability of two small intracranial aneurysms detected by presymptomatic screening.

Typical infantile appearance of autosomal recessive polycystic kidney disease.

The kidneys of autosomal recessive polycystic kidney disease (ARPKD) patients surviving the neonatal period often decrease in size and become fibrotic. Late manifestations of ARPKD are often related to hepatic fibrosis and intrahepatic dilatation of bile ducts (Caroli's disease).

Origin of renal cysts in autosomal recessive polycystic kidney disease and autosomal dominant polycystic kidney disease.

Origin of biliary fibrocystic disease in autosomal recessive polycystic kidney disease and autosomal dominant polycystic kidney disease.

Natural history of ADPKD. Renal function remains normal for decades despite unrelenting cystic disease progression.