Noninvasive Characterization of Renal Stones Project

Principal investigator:
Cynthia H. McCollough, Ph.D.

The long-term goal of the Noninvasive Characterization of Renal Stones Project in the O'Brien Urology Research Center at Mayo Clinic is to use advanced CT methodologies to characterize urinary calculi for the purpose of directing clinical treatment and facilitating clinical investigation.

Based on our extensive work in this field, we already know that dual energy CT can discriminate between uric acid and non-uric acid urinary stones. Our current objectives are:

  • To expand the number of stone types that can be differentiated
  • To provide accurate quantification of stone morphology (for example, shape, volume, surface and interior structure)
  • To develop a comprehensive, low-dose, stone-characterization exam using commercially available dual energy CT technology
  • To detect stone precursor lesions in specimens using a prototype CT system equipped with energy-resolving detectors

Findings will greatly improve the ability to conduct noninvasive clinical research protocols, as well as to accurately diagnose and monitor patients.

The Noninvasive Characterization of Renal Stones Project synergistically interacts with the CT and Urinary Correlates of Renal Stone Precursor Lesions Project and the Epidemiology of Nephrolithiasis and Chronic Kidney Disease Project.