CT and Urinary Correlates of Renal Stone Precursor Lesions Project

Mixed calcium oxalate monohydrate and hydroxyapatite urinary stone by micro CT

Principal investigator:
John C. Lieske, M.D.

Recent research has highlighted the importance of renal stone precursor lesions such as Randall's plaques. These studies, however, have necessitated a relatively invasive protocol, involving capillary tip biopsy and stone removal. Therefore, the CT and Urinary Correlates of Renal Stone Precursor Lesions Project in Mayo Clinic's O'Brien Urology Research Center has two broad aims.

The first aim is to correlate findings on ureteroscopic mapping with visualization by CT in order to define the limits of detection with modern dual energy CT scans. This research is performed in close collaboration with the Noninvasive Characterization of Renal Stones Project.

The second aim is to use CT mapping studies to phenotype patients' renal precursor lesions, which are then correlated with urinary composition, including supersaturation characteristics, urinary inhibitor activity and proteomics profile.

Better understanding the factors that drive formation of kidney stone precursor lesions will bring scientists one step closer to understanding the key pathogenic events in kidney stone formation and devising appropriate preventative regimens.