Ischemic Heart Disease Program
The Ischemic Heart Disease Program focuses on research related to coronary artery disease and other diseases that cause myocardial ischemia.
Regenerative medicine studies are a high priority and are coordinated with the National Heart, Lung, and Blood Institute-sponsored Cardiovascular Cell Therapy Research Network.
Researchers are enrolling patients in randomized clinical trials exploring the efficacy of cardiac delivery of autologous CD34+ bone-marrow-derived stem cells following acute myocardial infarction and refractory angina.
Studies in the program also are focused on individualized medicine, with a major priority being the Tailored Antiplatelet Initiation to Lesson Outcomes Due to Decreased Clopidogrel Response After Percutaneous Coronary Intervention (TAILOR-PCI) trial, which is funded by the Mayo Clinic Center for Individualized Medicine.
This prospective, international, multicenter, randomized trial is testing the hypothesis that using a genotype-guided dual anti-platelet therapy strategy in patients undergoing percutaneous coronary intervention will result in significantly improved cardiovascular outcomes in patients with reduced-function CYP2C19 allele(s).
Coronary physiology and imaging
The Heart and Lung Research Center and Mayo Clinic are focused on evaluating coronary endothelial function and microvascular disease in those with symptoms of myocardial ischemia with normal coronary arteries or mild atherosclerosis.
Mayo researchers are evaluating new risk factors and candidate genes that confer risk for endothelial dysfunction and conducting a National Institutes of Health-funded clinical trial exploring novel mechanisms and therapies for endothelial dysfunction.
Spontaneous coronary dissection
The group is looking at the mechanisms and genetics of spontaneous coronary dissection, one of the major causes of myocardial infarction in young women.
Percutaneous and surgical revascularization
Mayo researchers are active participants in international, multicenter, randomized clinical trials exploring key areas of clinical uncertainty in percutaneous and surgical revascularization.
Mayo Clinic physicians and researchers have strong expertise in the area of stress cardiomyopathy. An important differential diagnosis of acute coronary syndrome is the relatively recently described condition called apical balloon syndrome, also known as takotsubo cardiomyopathy or stress cardiomyopathy.
Mayo Clinic has a prospective registry for apical ballooning syndrome, and Mayo researchers are participating in an international registry to better understand the clinical features and outcomes of patients with this unique condition, which predominantly occurs in postmenopausal women.