Research Support

Current Research Support

Source/Number	Title and Description	Principal Investigator	Duration
NIH/NIBIB / R01 EB07986-01	Non-Invasive Localization of Vulnerable Plaques The goal of this proposal is to design a non-invasive CT-based imaging technique that localizes vulnerable plaques by virtue of iron accumulation in the coronary artery wall of asymptomatic patients who are at high risk of myocardial infarction.	Cynthia H. McCollough, Ph.D.	09/25/2007–08/31/2010
Society of Gastroenterologists / FP00050414	Development of Novel Tools for Projection and Image Space Denoising to Improve Image Quality and Reduce Radiation Dose at Contrast-enhanced Abdominal CT This award allows use of novel projection and image space denoising tools to permit radiation dose reduction and image quality improvement in CT enterography.	Joel G. Fletcher, M.D.	02/01/2008–01/31/2009
NIH/NIBIB / EB04898	Monte Carlo-Based Patient Radiation Dose from CT This multi-center research effort focuses on the extension of a previously validated Monte Carlo model to take into account different CT scanner geometries, beam widths and tube current modulation and to estimate dose to critical organs from various imaging protocols for voxelized patient models.	Michael F. McNitt-Gray, PhD, DABR — Role: Principal Investigator for Mayo sub-award	09/15/2005–06/30/2009
NIH/NHLBI / HR46158-01	Lung Tissue Research Consortium (LTRC) This multicenter research effort will obtain tissue samples of patients having diffuse lung disease and use epidemiological, pathological, and radiological methods to better understand diffuse lung pathology and to find the markers predictive of future disease.	Brian J. Bartholmai, M.D. — Role: Co-Investigator	01/01/2004–01/31/2009
National Cancer Institute (NCI) / CA 75333	CTC of the Unprepped Colon: Optimization and Validation To extend CT colography to the unprepped colon while maintaining high sensitivity and specificity.	C Daniel Johnson, M.D. — Role: Co-Investigator	09/01/2002–08/31/2007
NIH/NHLBI / AR 27065-28	Epidemiology of Bone Loss and Fracture To study risk factors for osteoporosis using conventional methodology and population-based studies, as well as volumetric quantitative CT and ultra-high resolution peripheral quantitative CT.	Sundeep Khosla, M.D. — Role: Co-Investigator	06/03/2005–05/31/2010
Berlex Laboratories / Berlex #36	Optimization for Dual-Source CT Imaging The purpose of this project is to develop and optimize clinical scan protocols, including contrast administration, data analysis and image review for dual-energy CT utilizing dual-source technology.	Cynthia H. McCollough, Ph.D.	08/15/2006–08/14/2008
Siemens Medical Solutions / INDUSSIEMENS #4-1	Clinical Innovation Center Grant The CT Clinical Innovation Center supports technical, feasibility and clinical studies focusing on quantitation of normal and pathological processes, early detection of disease, radiation dose reduction, and improving the care of difficult-to-image patients.	Cynthia H. McCollough, Ph.D.	08/01/2004–12/31/2009
Siemens Medical Solutions / INDUSSIEMENS #5-1	Clinical Innovation Center Grant This award supports the administrative effort associated with the efforts of the CT Clinical Innovation Center directed by Dr. McCollough.	Cynthia H. McCollough, Ph.D.
RTI Electronics AB / RTIEL #1	Evaluate Performance of Potential Applications for CT-SD16 The purpose of this work is to determine the accuracy and precision of, and potential applications for, a high-spatial resolution, high-temporal resolution novel CT dosimetry system.	Cynthia H. McCollough, Ph.D.	08/01/2006–07/31/2008

Completed Research Support

Source / Number	Title and Description	Principal Investigator	Duration
NIH/NHLBI / AR 27065-27	Epidemiology of Bone Loss and Fracture To study risk factors for osteoporosis using conventional methodology and population-based studies, as well as volumetric quantitative computed tomography and ultra-high resolution peripheral quantitative computed tomography.	Sundeep Khosla, M.D. — Role: Co-Investigator	06/01/2000–05/31/2005
Flight Attendant Medical Research Institute (FAMRI) / RR071L	ECG-gated Multidetector CT and Aortic Distensibility Aortic distensibility has been shown to be a predictor of cardiovascular disease using indirect measurement techniques. In this study, we investigate a direct method to quantitate aortic distensibility using ECG-gated CT.	Joel G. Fletcher, M.D. — Role: Co-Investigator	07/01/2004–06/30/2007
NIH / R01 HD38666-4	Anorectal Manifestations of Female Pelvic Floor Disorders The major goal of this project is to evaluate the role of disturbances in rectal compliance and sensation in pelvic floor abnormalities in fecal continence and obstructed defecation. These studies will be conducted in Clinic patients.	Adil E. Bharucha, M.B.B.S., M.D. — Role: Co-Investigator	06/01/2006–03/31/2008
NIH / R01 HD41129-5	Epidemiology and Mechanisms of Fecal Incontinence The major goal of this project is to define in detail the epidemiology of fecal incontinence in women. The overall objective of this proposal is to better understand the epidemiology and pathophysiology of fecal incontinence (FI) by combining the data infrastructure of the Rochester Epidemiology Project medical records-linkage system with state-of-the-art physiological measurements.	Adil E. Bharucha, M.B.B.S., M.D. — Role: Co-Investigator	09/01/2001–07/31/2008
Protein Design Lab / INDUSPROTEIN#7	A Phase IIa, Open-label Study of Visilizumab for Treatment of Perianal Fistulas in Patients with Crohn's Disease The major goal is to detect and grade perianal fistulas in patients treated with visilizumab.	Joel G. Fletcher, M.D.	08/01/2005–07/31/2008
ACRIN 6664	National CT Colonography Screening Trial	Role: Consultant	12/2004–02/2006
Eagles Cancer Fund	Contrast-Enhanced CT Colonography: Estimating Sensitivity and Specificity in Detecting Recurrent Colorectal Carcinoma	Joel G. Fletcher, M.D.	05/1999–04/2000