Publications

  1. Tiedemann RL, Putiri EL, Lee JH, Hlady RA, Kashiwagi K, Ordog T, Zhang Z, Liu C, Choi JH, Robertson KD. Acute Depletion Redefines the Division of Labor among DNA Methyltransferases in Methylating the Human Genome. Cell Rep. 2014 Nov 20; 9(4):1554-66. Epub 2014 Nov 6
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  2. Zhao X, Puszyk WM, Lu Z, Ostrov D, George T, Robertson K, Liu C. Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma. Mol Cancer Ther. 2014 Oct 24.
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  3. Hlady RA, Tiedemann RL, Puszyk W, Zendejas I, Roberts LR, Choi JH, Liu C, Robertson KD. Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis. Oncotarget. 2014 Oct 15; 5(19):9425-43.
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  4. Putiri EL, Tiedemann RL, Liu C, Choi JH, Robertson KD. Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome. Oncotarget. 2014 Aug 30; 5(15):6338-52.
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  5. Putiri EL, Tiedemann RL, Thompson JJ, Liu CS, Ho T, Choi JH, Robertson KD. Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the tet proteins in human cancer cells. Genome Biol. 2014; 15(6):R81.
  6. Zimmerman MA, Singh N, Martin PM, Thangaraju M, Ganapathy V, Waller JL, Shi H, Robertson KD, Munn DH, Liu K. Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15; 302(12):G1405-15. Epub 2012 Apr 19.
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  7. Jin B, Ernst J, Tiedemann RL, Xu H, Sureshchandra S, Kellis M, Dalton S, Liu C, Choi J-H, Robertson KD. Linking DNA methyltransferases (DNMTs) to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Rep. 2012; 2(5):1411-1424.
  8. Yoo J, Kim JH, Robertson KD, Medina-Franco JL. Molecular modeling of inhibitors of human DNA methyltransferase with a crystal structure: discovery of a novel DNMT1 inhibitor. Adv Protein Chem Struct Biol. 2012; 87:219-47.
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  9. Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, Koomen J, Chen J, Lane WS, Seto E. SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities. Mol Cell Biol. 2011 Dec; 31(23):4720-34. Epub 2011 Sep 26.
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  10. Liu F, Liu Q, Yang D, Bollag WB, Robertson K, Wu P, Liu K. Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3. Cancer Res. 2011 Nov 1; 71(21):6807-16. Epub 2011 Sep 12.
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  11. Lee EJ, Pei L, Srivastava G, Joshi T, Kushwaha G, Choi JH, Robertson KD, Wang X, Colbourne JK, Zhang L, Schroth GP, Xu D, Zhang K, Shi H. Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing. Nucleic Acids Res. 2011 Oct; 39(19):e127. Epub 2011 Jul 23
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  12. Van Emburgh BO, Robertson KD. Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants. Nucleic Acids Res. 2011 Jul; 39(12):4984-5002. Epub 2011 Mar 04.
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  13. Liu H, Dong H, Robertson K, Liu C. DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma. Am J Pathol. 2011 Feb; 178(2):652-61.
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  14. Dyer LM, Schooler KP, Ai L, Klop C, Qiu J, Robertson KD, Brown KD. The transglutaminase 2 gene is aberrantly hypermethylated in glioma. J Neurooncol. 2011 Feb; 101(3):429-40. Epub 2010 Jul 03.
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  15. Ha K, Lee GE, Palii SS, Brown KD, Takeda Y, Liu K, Bhalla KN, Robertson KD. Rapid and transient recruitment of DNMT1 to DNA double strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery. Hum Mol Genet. 2010; 20(1):126-140.
  16. Gopalakrishnan S, Van Emburgh BO, Shan J, Su Z, Fields CR, Vieweg J, Hamazaki T, Schwartz PH, Terada N, Robertson KD. A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding. Mol Cancer Res. 2009 Oct; 7(10):1622-34. Epub 2009 Oct 13.
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  17. Jin B, Yao B, Li JL, Fields CR, Delmas AL, Liu C, Robertson KD. DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer. Cancer Res. 2009 Sep 15; 69(18):7412-21. Epub 2009 Sep 1
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  18. Gopalakrishnan S, Sullivan BA, Trazzi S, Della Valle G, Robertson KD. DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum Mol Genet. 2009 Sep 1; 18(17):3178-93. Epub 2009 May 29.
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  19. Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest. 2009 Sep; 89(9):983-93. Epub 2009 Jun 22
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  20. Zeng W, de Greef JC, Chen YY, Chien R, Kong X, Gregson HC, Winokur ST, Pyle A, Robertson KD, Schmiesing JA, Kimonis VE, Balog J, Frants RR, Ball AR Jr, Lock LF, Donovan PJ, van der Maarel SM, Yokomori K. Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD). PLoS Genet. 2009 Jul; 5(7):e1000559. Epub 2009 Jul 10
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  21. Gopalakrishnan S, Van Emburgh BO, Robertson KD. DNA methylation in development and human disease. Mutat Res. 2008 Dec 1; 647(1-2):30-8. Epub 2008 Aug 20.
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  22. Jin B, Tao Q, Peng J, Soo HM, Wu W, Ying J, Fields CR, Delmas AL, Liu X, Qiu J, Robertson KD. DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum Mol Genet. 2008 Mar 1; 17(5):690-709. Epub 2007 Nov 20.
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  23. Palii SS, Van Emburgh BO, Sankpal UT, Brown KD, Robertson KD. DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol Cell Biol. 2008 Jan; 28(2):752-71. Epub 2007 Nov 08.
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  24. Qiu J, Ai L, Ramachandran C, Yao B, Gopalakrishnan S, Fields CR, Delmas AL, Dyer LM, Melnick SJ, Yachnis A, Schwartz PH, Fine HA, Brown KD, Robertson KD. Invasion suppressor CST6 (cystatin E/M): High-level cell type-specific expression in normal brain and epigenetic silencing in gliomas. Lab Invest. 2008; 88(9):910-925.
  25. Demircan B, Dyer LM, Gerace M, Lobenhofer EK, Robertson KD, Brown KD. Comparative epigenomics of human and mouse mammary tumors. Genes Chromosomes Cancer. 2008; 48(1):83-97.
  26. Chan SL, Cui Y, van Hasselt A, Li H, Srivastava G, Jin H, Ng KM, Wang Y, Lee KY, Tsao GS, Zhong S, Robertson KD, Rha SY, Chan AT, Tao Q. The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. Lab Invest. 2007 Jul; 87(7):644-50. Epub 2007 Mar 26.
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  27. Zhong S, Fields CR, Su N, Pan YX, Robertson KD. Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. Oncogene. 2007 Apr 19; 26(18):2621-34. Epub 2006 Oct 9
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  28. Zhao LY, Niu Y, Santiago A, Liu J, Albert SH, Robertson KD, Liao D. An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis. Cancer Res. 2006 Oct 1; 66(19):9445-52.
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  29. Kim TY, Zhong S, Fields CR, Kim JH, Robertson KD. Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res. 2006 Aug 1; 66(15):7490-501.
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  30. Ai L, Tao Q, Zhong S, Fields CR, Kim WJ, Lee MW, Cui Y, Brown KD, Robertson KD. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis. 2006 Jul; 27(7):1341-8. Epub 2006 Feb 25
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  31. Ai L, Kim T-Y, Kim W-J, Fields CR, Massoll NA, Robertson KD, Brown KD. Epigenetic silencing of the metastasis suppressor cystatin M occurs during breast cancer progression. Cancer Res. 2006; 66(16):7899-7909.
  32. Robertson KD. DNA methylation and human disease. Nat Rev Genet. 2005 Aug; 6(8):597-610.
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  33. Yokochi T, Robertson KD. Doxorubicin inhibits DNMT1, resulting in conditional apoptosis. Mol Pharmacol. 2004 Dec; 66(6):1415-20. Epub 2004 Aug 31.
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  34. Robertson AK, Geiman TM, Sankpal UT, Hager GL, Robertson KD. Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):110-8.
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  35. Espada J, Ballestar E, Fraga MF, Villar-Garea A, Juarranz A, Stockert JC, Robertson KD, Fuks F, Esteller M. Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern. J Biol Chem. 2004 Aug 27; 279(35):37175-84. Epub 2004 Jun 25.
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  36. Yokochi T, Robertson KD. Dimethyl sulfoxide stimulates the catalytic activity of de novo DNA methyltransferase 3a (Dnmt3a) in vitro. Bioorg Chem. 2004 Aug; 32(4):234-43.
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  37. Geiman TM, Sankpal UT, Robertson AK, Zhao Y, Zhao Y, Robertson KD. DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem Biophys Res Commun. 2004 May 28; 318(2):544-55.
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  38. Chan AT, Tao Q, Robertson KD, Flinn IW, Mann RB, Klencke B, Kwan WH, Leung TW, Johnson PJ, Ambinder RF. Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors. J Clin Oncol. 2004 Apr 15; 22(8):1373-81. Epub 2004 Mar 8
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  39. Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD. Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res. 2004; 32(9):2716-29. Epub 2004 May 17.
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  40. Ling Y, Sankpal UT, Robertson AK, McNally JG, Karpova T, Robertson KD. Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 2004; 32(2):598-610. Epub 2004 Jan 29
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  41. Tao Q, Huang H, Geiman TM, Lim CY, Fu L, Qiu GH, Robertson KD. Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells. Hum Mol Genet. 2002 Sep 1; 11(18):2091-102.
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  42. Yokochi T, Robertson KD. Preferential methylation of unmethylated DNA by Mammalian de novo DNA methyltransferase Dnmt3a. J Biol Chem. 2002 Apr 5; 277(14):11735-45. Epub 2002 Jan 30.
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  43. Robertson KD. DNA methylation, methyltransferases, and cancer. Oncogene. 2001 May 28; 20(24):3139-55.
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  44. Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet. 2000 Oct; 1(1):11-9.
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  45. Liang G, Robertson KD, Talmadge C, Sumegi J, Jones PA. The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells. Cancer Res. 2000 Sep 1; 60(17):4907-12.
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  46. Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet. 2000 Jul; 25(3):338-42.
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  47. Robertson KD, Keyomarsi K, Gonzales FA, Velicescu M, Jones PA. Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells. Nucleic Acids Res. 2000 May 15; 28(10):2108-13.
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  48. Bender CM, Gonzalgo ML, Gonzales FA, Nguyen CT, Robertson KD, Jones PA. Roles of cell division and gene transcription in the methylation of CpG islands. Mol Cell Biol. 1999 Oct; 19(10):6690-8.
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  49. Tao Q, Swinnen LJ, Yang J, Srivastava G, Robertson KD, Ambinder RF. Methylation status of the Epstein-Barr virus major latent promoter C in iatrogenic B cell lymphoproliferative disease. Application of PCR-based analysis. Am J Pathol. 1999 Aug; 155(2):619-25.
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  50. Robertson KD, Jones PA. Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus. Oncogene. 1999 Jul 1; 18(26):3810-20.
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  51. Robertson KD, Uzvolgyi E, Liang G, Talmadge C, Sumegi J, Gonzales FA, Jones PA. The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res. 1999 Jun 1; 27(11):2291-8.
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  52. Robertson KD, Jones PA. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol. 1998 Nov; 18(11):6457-73.
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  53. Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF. Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: molecular analysis of primary tumor tissue. Blood. 1998 Feb 15; 91(4):1373-81.
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  54. Tao Q, Robertson KD, Manns A, Hildesheim A, Ambinder RF. The Epstein-Barr virus (EBV) latent promoter Qp is constitutively active, hypomethylated, and methylation sensitive. J Virol. 1998; 72(9):7075-83.
  55. Robertson KD, Ambinder RF. Methylation of the Epstein-Barr virus genome in normal lymphocytes. Blood. 1997 Dec 1; 90(11):4480-4.
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  56. Robertson KD, Jones PA. Dynamic interrelationships between DNA replication, methylation, and repair. Am J Hum Genet. 1997 Dec; 61(6):1220-4.
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  57. Robertson KD, Ambinder RF. Mapping promoter regions that are hypersensitive to methylation-mediated inhibition of transcription: application of the methylation cassette assay to the Epstein-Barr virus major latency promoter. J Virol. 1997 Sep; 71(9):6445-54.
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  58. Robertson KD, Manns A, Swinnen LJ, Zong JC, Gulley ML, Ambinder RF. CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's disease. Blood. 1996 Oct 15; 88(8):3129-36.
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  59. Robertson KD, Hayward SD, Ling PD, Samid D, Ambinder RF. Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial. Mol Cell Biol. 1995 Nov; 15(11):6150-9.
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  60. Bolton MG, Hilton J, Robertson KD, Streeper RT, Colvin OM, Noe DA. Kinetic analysis of the reaction of melphalan with water, phosphate, and glutathione. Drug Metab Dispos. 1993 Nov-Dec; 21(6):986-96.
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