Publications

  1. Ferrajoli A, Shanafelt TD, Ivan C, Shimizu M, Rabe KG, Nouraee N, Ikuo M, Ghosh AK, Lerner S, Rassenti LZ, Xiao L, Hu J, Reuben JM, Calin S, You MJ, Manning JT, Wierda WG, Estrov Z, O'Brien S, Kipps TJ, Keating MJ, Kay NE, Calin GA. Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood. 2013 Sep 12; 122(11):1891-9. Epub 2013 Jul 02.
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  2. Ghosh AK, Kay NE. Critical signal transduction pathways in CLL. Adv Exp Med Biol. 2013; 792:215-39.
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  3. Shanafelt TD, Call TG, Zent CS, Leis JF, LaPlant B, Bowen DA, Roos M, Laumann K, Ghosh AK, Lesnick C, Lee MJ, Yang CS, Jelinek DF, Erlichman C, Kay NE. Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia. Cancer. 2013 Jan 15; 119(2):363-70. Epub 2012 Jul 03.
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  4. Ghosh AK, Secreto C, Boysen J, Sassoon T, Shanafelt TD, Mukhopadhyay D, Kay NE. The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy. Blood. 2011 Feb 10; 117(6):1928-37. Epub 2010 Dec 6
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  5. Shanafelt T, Zent C, Byrd J, Erlichman C, Laplant B, Ghosh A, Call T, Villalona-Calero M, Jelinek D, Bowen D, Laumann K, Wu W, Hanson C, Kay N. Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia. Leuk Lymphoma. 2010 Dec; 51(12):2222-9. Epub 2010 Nov 05.
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  6. Ghosh AK, Secreto CR, Knox TR, Ding W, Mukhopadhyay D, Kay NE. Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression. Blood. 2010 Mar 4; 115(9):1755-64. Epub 2009 Dec 17.
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  7. Sinha S, Dutta S, Datta K, Ghosh AK, Mukhopadhyay D. Von Hippel-Lindau gene product modulates TIS11B expression in renal cell carcinoma: impact on vascular endothelial growth factor expression in hypoxia. J Biol Chem. 2009 Nov 20; 284(47):32610-8. Epub 2009 Sep 28.
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  8. Ding W, Nowakowski GS, Knox TR, Boysen JC, Maas ML, Schwager SM, Wu W, Wellik LE, Dietz AB, Ghosh AK, Secreto CR, Medina KL, Shanafelt TD, Zent CS, Call TG, Kay NE. Bi-directional activation between mesenchymal stem cells and CLL B-cells: implication for CLL disease progression. Br J Haematol. 2009 Nov; 147(4):471-83. Epub 2009 Sep 08.
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  9. Shanafelt TD, Call TG, Zent CS, LaPlant B, Bowen DA, Roos M, Secreto CR, Ghosh AK, Kabat BF, Lee MJ, Yang CS, Jelinek DF, Erlichman C, Kay NE. Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia. J Clin Oncol. 2009 Aug 10; 27(23):3808-14. Epub 2009 May 26.
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  10. Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. 2009 May 28; 113(22):5568-74. Epub 2009 Mar 31.
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  11. Ghosh AK, Kay NE, Secreto CR, Shanafelt TD. Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Clin Cancer Res. 2009 Feb 15; 15(4):1250-8.
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  12. Ghosh AK, Kanda T, Steele R, Ray RB. Knockdown of MBP-1 in human foreskin fibroblasts induces p53-p21 dependent senescence. PLoS One. 2008; 3(10):e3384. Epub 2008 Oct 13.
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  13. Ghosh AK, Steele R, Ryerse J, Ray RB. Tumor-suppressive effects of MBP-1 in non-small cell lung cancer cells. Cancer Res. 2006 Dec 15; 66(24):11907-12.
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  14. Ghosh AK, Steele R, Ray RB. Knockdown of MBP-1 in human prostate cancer cells delays cell cycle progression. J Biol Chem. 2006 Aug 18; 281(33):23652-7. Epub 2006 Jun 08.
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  15. Ghosh AK, Steele R, Ray RB. Carboxyl-terminal repressor domain of MBP-1 is sufficient for regression of prostate tumor growth in nude mice. Cancer Res. 2005 Feb 1; 65(3):718-21.
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  16. Ghosh AK, Steele R, Ray RB. c-myc Promoter-binding protein 1 (MBP-1) regulates prostate cancer cell growth by inhibiting MAPK pathway. J Biol Chem. 2005 Apr 8; 280(14):14325-30. Epub 2005 Feb 01.
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  17. Sarcar B, Ghosh AK, Steele R, Ray R, Ray RB. Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase. Virology. 2004 Apr 25; 322(1):51-60.
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  18. Ray RB, Basu A, Steele R, Beyene A, McHowat J, Meyer K, Ghosh AK, Ray R. Ebola virus glycoprotein-mediated anoikis of primary human cardiac microvascular endothelial cells. Virology. 2004 Apr 10; 321(2):181-8.
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  19. Majumder M, Steele R, Ghosh AK, Zhou XY, Thornburg L, Ray R, Phillips NJ, Ray RB. Expression of hepatitis C virus non-structural 5A protein in the liver of transgenic mice. FEBS Lett. 2003 Dec 18; 555(3):528-32.
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  20. Sen A, Steele R, Ghosh AK, Basu A, Ray R, Ray RB. Inhibition of hepatitis C virus protein expression by RNA interference. Virus Res. 2003 Oct; 96(1-2):27-35.
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  21. Ghosh AK, Steele R, Ray RB. Modulation of human luteinizing hormone beta gene transcription by MIP-2A. J Biol Chem. 2003 Jun 27; 278(26):24033-8. Epub 2003 Apr 16.
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  22. Mukherjee P, Ghosh AK, Ghose AC. Infection pattern and immune response in the spleen and liver of BALB/c mice intracardially infected with Leishmania donovani amastigotes. Immunol Lett. 2003 Apr 3; 86(2):131-8.
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  23. Ghosh AK, Majumder M, Steele R, Ray R, Ray RB. Modulation of interferon expression by hepatitis C virus NS5A protein and human homeodomain protein PTX1. Virology. 2003 Feb 1; 306(1):51-9.
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  24. Ray RB, Steele R, Basu A, Meyer K, Majumder M, Ghosh AK, Ray R. Distinct functional role of Hepatitis C virus core protein on NF-kappaB regulation is linked to genomic variation. Virus Res. 2002 Jul; 87(1):21-9.
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  25. Ghosh AK, Majumder M, Steele R, Liu TJ, Ray RB. MBP-1 mediated apoptosis involves cytochrome c release from mitochondria. Oncogene. 2002 Apr 25; 21(18):2775-84.
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  26. Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB. Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice. Virology. 2002 Mar 1; 294(1):94-105.
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  27. Majumder M, Ghosh AK, Steele R, Ray R, Ray RB. Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner. J Virol. 2001 Feb; 75(3):1401-7.
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  28. Ghosh AK, Majumder M, Steele R, White RA, Ray RB. A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1. Mol Cell Biol. 2001 Jan; 21(2):655-62.
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  29. Ghosh AK, Majumder M, Steele R, Meyer K, Ray R, Ray RB. Hepatitis C virus NS5A protein protects against TNF-alpha mediated apoptotic cell death. Virus Res. 2000 Apr; 67(2):173-8.
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  30. Ghosh AK, Majumder M, Steele R, Yaciuk P, Chrivia J, Ray R, Ray RB. Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP. J Biol Chem. 2000 Mar 10; 275(10):7184-8.
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  31. Ghosh AK, Grigorieva I, Steele R, Hoover RG, Ray RB. PTEN transcriptionally modulates c-myc gene expression in human breast carcinoma cells and is involved in cell growth regulation. Gene. 1999 Jul 22; 235(1-2):85-91.
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  32. Ghosh AK, Steele R, Ray RB. MBP-1 physically associates with histone deacetylase for transcriptional repression. Biochem Biophys Res Commun. 1999 Jul 5; 260(2):405-9.
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  33. Ghosh AK, Steele R, Meyer K, Ray R, Ray RB. Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth. J Gen Virol. 1999 May; 80 ( Pt 5):1179-83.
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  34. Ghosh AK, Steele R, Ray RB. Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation. Mol Cell Biol. 1999 Apr; 19(4):2880-6.
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  35. Ghose AC, Mookerjee A, Sengupta K, Ghosh AK, Dasgupta S, Ray PK. Therapeutic and prophylactic uses of protein A in the control of Leishmania donovani infection in experimental animals. Immunol Lett. 1999 Feb; 65(3):175-81.
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  36. Ray RB, Ghosh AK, Meyer K, Ray R. Functional analysis of a transrepressor domain in the hepatitis C virus core protein. Virus Res. 1999 Feb; 59(2):211-7.
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  37. Ghosh MK, Ghosh AK, Addy M, Nandy A, Ghose AC. Subpopulations of T lymphocytes in the peripheral blood and lymph nodes of Indian kala-azar patients. Med Microbiol Immunol. 1996 Nov; 185(3):183-7.
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  38. Ghosh AK, Dasgupta S, Ghose AC. Immunoglobulin G subclass-specific antileishmanial antibody responses in Indian kala-azar and post-kala-azar dermal leishmaniasis. Clin Diagn Lab Immunol. 1995 May; 2(3):291-6.
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