Publications

  1. Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM. Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science 2016 Oct 28; 354 (6311):472-477 Epub 2016 Oct 27
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  2. Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM. Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Science 2016 Sep 30; 353 (6307):1549-1552
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  3. Choi CI, Yoo KH, Hussaini SM, Jeon BT, Welby J, Gan H, Scarisbrick I, Zhang Z, Baker DJ, van Deursen JM, Rodriguez M, Jang MH. The progeroid gene BubR1 regulates axon myelination and motor function. Aging (Albany NY) 2016 Sep 12 Epub 2016 Sept 12
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  4. Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM. BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer. Elife 2016 Aug 16; 5
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  5. Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM. Bubr1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer ELIFE 2016 Aug 16; 5:e16620
  6. Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue. Diabetes 2016 Jun; 65 (6):1606-15 Epub 2016 Mar 16
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  7. Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T. Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown. Stroke 2016 Apr; 47 (4):1068-77 Epub 2016 Feb 16
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  8. Andriani GA, Faggioli F, Baker D, Dolle ME, Sellers RS, Hebert JM, Van Steeg H, Hoeijmakers J, Vijg J, Montagna C. Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Delta7 mice. Hum Mol Genet 2016 Feb 15; 25 (4):755-65 Epub 2015 Dec 17
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  9. Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature 2016 Feb 11; 530 (7589):184-9 Epub 2016 Feb 03
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  10. Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, Van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, Van Ree JH, Mer G, Shapiro VS, Maher LJ III, Katzmann DJ, Van Deursen JM. Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation Science 2016; 353 (6307):1549-52
  11. Verma SS, Cooke Bailey JN, Lucas A, Bradford Y, Linneman JG, Hauser MA, Pasquale LR, Peissig PL, Brilliant MH, McCarty CA, Haines JL, Wiggs JL, Vrabec TR, Tromp G, Ritchie MD, Bickel J, Chandler A, Holm I, Kohane I, Manzi S, Markianos K, Palmer N, Perry C, Savova G, Wolf W, Wong Kong S, Antommaria A, Cobb B, Harley J, Hutton J, Lingren T, Lynch J, Marsolo K, Myers M, Namjou B, Prows C, Solti I, Vinks S, Wagner M, Abrams D, Almoguera B, Chiavacci R, Connolly J, Devoto M, Hakonarson H, Keating B, Kim C, Mentch F, Qui H, Sleiman P, Tian L, Vazquez L, Bartko B, Bock J, Borthwick K, Carey D, Colonie R, Elston R, Faucett A, Fetterolf S, Gerhard G, Kuivaniemi H, Ledbetter D, Lipsky E, Pendergrass S, Sundaresan A, Smelser D, Williams J, Williams M, Wood C, Albrecht J, Carlson C, Carrell D, Crane P, Cronkite D, Crosslin D, Davis C, Ehrlich K, Fullterton M, Gallego C, Gordon A, Grafton J, Hansen K, Hartzler A, Jarvik G, Larson E, Leppig K, Mukherjee S, Ralston J, Scrol A, Tarczy-Hornoch P, Trinidad S, Bielinski S, Bruce K, Chute C, De Andrade M, Jouni H, Heit J, Isseh I, Koenig B, Kullo I, Li D, McCormick J, Pathak J, Russell J, Schultz C, Vitek C, Wussow L, Sharp R, Olson A, Chandra H, Armstrong G, Berg R, Brautbar A, Brilliant M, Finamore J, Frost N, Hall M, He M, Kitchner T, Lin S, Linneman J, McCarty C, Peissig P, Shefali S, Strenn R, Weichelt B, Bagiella E, Bottinger E, Dieterich D, Ellis S, Ferryman K, Friedman C, Friedman S, Galarneau G, Gomez A, Gottesman O, Hulot JS, Horowitz C, Hripcsak G, Kannry J, Kenny E, Keppel Y, Lin J, Lotay V, Mejia A, Nadukuru R, Peter I, Rhodes R, Sanderson S, Scott S, Ullman T, Weijia Z, Weng C, Zinberg R, Armstrong L, Aufox S, Baker D, Cameron K, Chisholm R, Christensen C, Greenland P, Hayes G, Heathcote M, Kho A, Lowe B, Jackson K, Pacheco J, Pan V, Persell S, Rasmussen L, Rasmussen-Torvik L, Smith M, Starren J, Thompson W, Wicklund C, Brothers K, Chen L, Clayton E, Cowan J, Crawford D, Denny J, Edwards T, Harris P, Garrison N, Malin B, McGregor T, Peterson J, Roden D, Speltz P, Stallings S, Stroud M, Velez D, Van Driest S, Wilke R, Basford M, Claar MB, Hardebeck A, Kirby J, Ritchie M, Setia S, Kaufman D, Li R, Manolio T, Allingham RR, Budenz DL, Kang JH, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Liu Y, Moroi SE, Realini A, Ritch R, Richards JE, Schuman JS, Scott B, Singh K, Vollrath D, Weinreb RN, Wollstein G, Yaspan BL, Yoneyama S, Zack D, Zhang K, Pericak-Vance M. Epistatic gene-based interaction analyses for glaucoma in eMERGE and NEIGHBOR consortium PLoS Genetics 2016; 12 (9):e1006186
  12. Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, Van Deursen JM. Senescent intimal foam cells are deleterious at all stages of atherosclerosis Science 2016; 354 (6311):472-7
  13. Childs BG, Durik M, Baker DJ, van Deursen JM. Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med 2015 Dec; 21 (12):1424-35
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  14. Baker DJ, Hommerding CJ, Childs BG. The Role of Stem Cell Genomic Instability in Aging Current Stem Cell Reports.1:(3):151-161.
  15. Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, Machida Y, van Deursen JM, Machida Y. Spartan deficiency causes genomic instability and progeroid phenotypes. Nat Commun 2014 Dec 11; 5:5744
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  16. Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep 2014 Nov; 15 (11):1139-53 Epub 2014 Oct 13
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  17. Wijshake T, Baker DJ, van de Sluis B. Endonucleases: new tools to edit the mouse genome. Biochim Biophys Acta 2014 Oct; 1842 (10):1942-1950 Epub 2014 Apr 30
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  18. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J 2014 Jul 1; 33 (13):1438-53 Epub 2014 May 12
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  19. Baker DJ, Weaver RL, van Deursen JM. p21 both attenuates and drives senescence and aging in BubR1 progeroid mice. Cell Rep 2013 Apr 25; 3 (4):1164-74 Epub 2013 Apr 18
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  20. Naylor RM, Baker DJ, van Deursen JM. Senescent cells: a novel therapeutic target for aging and age-related diseases. Clin Pharmacol Ther 2013 Jan; 93 (1):105-16 Epub 2012 Dec 05
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  21. Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol 2013 Jan; 15 (1):96-102 Epub 2012 Dec 16
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  22. Wijshake T, Malureanu LA, Baker DJ, Jeganathan KB, van de Sluis B, van Deursen JM. Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation. PLoS Genet 2012; 8 (12):e1003138 Epub 2012 Dec 27
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  23. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 2011 Nov 02; 479 (7372):232-6
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  24. Baker DJ. Hypomorphic mice. Methods Mol Biol. 2011; 693:233-44.
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  25. Malureanu L, Jeganathan KB, Jin F, Baker DJ, van Ree JH, Gullon O, Chen Z, Henley JR, van Deursen JM. Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis. J Cell Biol 2010 Oct 18; 191 (2):313-29
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  26. Li M, Fang X, Baker DJ, Guo L, Gao X, Wei Z, Han S, van Deursen, Zhang P. The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14188-93. Epub 2010 Jul 27.
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  27. Baker DJ, van Deursen JM. Chromosome missegregation causes colon cancer by APC loss of heterozygosity. Cell Cycle 2010 May; 9 (9):1711-6 Epub 2010 May 27
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  28. Baker DJ, Jin F, Jeganathan KB, van Deursen JM. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell 2009 Dec 8; 16 (6):475-86
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  29. Baker DJ, Jin F, van Deursen JM. The yin and yang of the Cdkn2a locus in senescence and aging. Cell Cycle 2008 Sep 15; 7 (18):2795-802 Epub 2008 Sept 28
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  30. Baker DJ, Perez-Terzic C, Jin F, Pitel KS, Niederlander NJ, Jeganathan K, Yamada S, Reyes S, Rowe L, Hiddinga HJ, Eberhardt NL, Terzic A, van Deursen JM. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol 2008 Jul; 10 (7):825-36 Epub 2008 May 30
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  31. Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM. Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol. 2007 Oct 22; 179(2):255-67. Epub 2007 Oct 15.
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  32. Matsumoto T, Baker DJ, d'Uscio LV, Mozammel G, Katusic ZS, van Deursen JM. Aging-associated vascular phenotype in mutant mice with low levels of BubR1. Stroke 2007 Mar; 38 (3):1050-6 Epub 2007 Feb 01
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  33. Baker DJ, Dawlaty MM, Galardy P, van Deursen JM. Mitotic regulation of the anaphase-promoting complex. Cell Mol Life Sci 2007 Mar; 64 (5):589-600
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  34. Baker DJ, Jeganathan KB, Malureanu L, Perez-Terzic C, Terzic A, van Deursen JM. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol 2006 Feb 13; 172 (4):529-40
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  35. Jeganathan KB, Baker DJ, van Deursen JM. Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Cell Cycle 2006 Feb; 5 (4):366-70 Epub 2006 Feb 15
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  36. Baker DJ, Chen J, van Deursen JM. The mitotic checkpoint in cancer and aging: what have mice taught us? Curr Opin Cell Biol. 2005 Dec; 17(6):583-9. Epub 2005 Oct 13.
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  37. Niessen P, Rensen S, van Deursen J, De Man J, De Laet A, Vanderwinden JM, Wedel T, Baker D, Doevendans P, Hofker M, Gijbeis M, van Eys G. Smoothelin-a is essential for functional smooth muscle contractility in mice. Gastroenterology. 2005; 129:1592-1601.
  38. Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 2004 Jul; 36 (7):744-9 Epub 2004 June 20
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  39. Kang-Decker N, Tong C, Boussouar F, Baker DJ, Xu W, Leontovich AA, Taylor WR, Brindle PK, van Deursen JM. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell 2004 Feb; 5 (2):177-89
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  40. Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol 2003 Feb 3; 160 (3):341-53 Epub 2003 Jan 27
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