Publications

  1. Bauer M, Glenn T, Alda M, Andreassen OA, Angelopoulos E, Ardau R, Baethge C, Bauer R, Bellivier F, Belmaker RH, Berk M, Bjella TD, Bossini L, Bersudsky Y, Cheung EY, Conell J, Zompo MD, Dodd S, Etain B, Fagiolini A, Frye MA, Fountoulakis KN, Relationship between sunlight and the age of onset of bipolar disorder: An international multisite study. J Affect Disord. 2014 Oct; 167:104-11. Epub 2014 May 29.
    View PubMed
  2. Bobo WV, Pathak J, Kremers HM, Yawn BP, Brue SM, Stoppel CJ, Croarkin PE, St Sauver J, Frye MA, Rocca WA. An electronic health record driven algorithm to identify incident antidepressant medication users. J Am Med Inform Assoc. 2014 Sep; 21(5):785-91. Epub 2014 Apr 29.
    View PubMed
  3. Winham SJ, Cuellar-Barboza AB, McElroy SL, Oliveros A, Crow S, Colby CL, Choi DS, Chauhan M, Frye MA, Biernacka JM. Bipolar disorder with comorbid binge eating history: a genome-wide association study implicates APOB. J Affect Disord. 2014 Aug; 165:151-8. Epub 2014 Apr 19.
    View PubMed
  4. Prieto ML, Cuellar-Barboza AB, Bobo WV, Roger VL, Bellivier F, Leboyer M, West CP, Frye MA. Risk of myocardial infarction and stroke in bipolar disorder: a systematic review and exploratory meta-analysis. Acta Psychiatr Scand. 2014 May 22. [Epub ahead of print]
    View PubMed
  5. Post RM, Altshuler L, Kupka R, McElroy S, Frye MA, Rowe M, Leverich GS, Grunze H, Suppes T, Keck PE Jr, Nolen WA. More pernicious course of bipolar disorder in the United States than in many European countries: implications for policy and treatment. J Affect Disord. 2014 May; 160:27-33. Epub 2014 Feb 10.
    View PubMed
  6. Post RM, Leverich GS, Kupka R, Keck P Jr, McElroy S, Altshuler L, Frye MA, Luckenbaugh DA, Rowe M, Grunze H, Suppes T, Nolen WA. Increased parental history of bipolar disorder in the united states: association with early age of onset. Acta Psychiatr Scand. 2014 May; 129(5):375-82.
  7. Grothe KB, Mundi MS, Himes SM, Sarr MG, Clark MM, Geske JR, Kalsy SA, Frye MA. Bipolar Disorder Symptoms in Patients Seeking Bariatric Surgery. Obes Surg. 2014 Apr 22.
    View PubMed
  8. Post RM, Altshuler LL, Leverich GS, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Kupka RW, Grunze H, Rowe M. More medical comorbidities in patients with bipolar disorder from the United States than from the Netherlands and Germany. J Nerv Ment Dis. 2014 Apr; 202(4):265-70.
    View PubMed
  9. Karpyak VM, Winham SJ, Biernacka JM, Cunningham JM, Lewis KA, Geske JR, Colby CL, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Frye MA, Heit JA, Mrazek DA. Association of GATA4 sequence variation with alcohol dependence. Addict Biol. 2014 Mar; 19(2):312-5. Epub 2012 Aug 02.
    View PubMed
  10. Kolla BP, Schneekloth T, Biernacka J, Mansukhani M, Geske J, Karpyak V, Hall-Flavin D, Louikianova L, Frye MA. The course of sleep disturbances in early alcohol recovery: an observational cohort study. Am J Addict. 2014 Jan-Feb; 23(1):21-6. Epub 2013 Jun 6
    View PubMed
  11. Altinbas K, Ozerdem A, Prieto ML, Fuentes ME, Yalin N, Ersoy Z, Aydemir O, Quiroz D, Oztekin S, Geske JR, Feeder SE, Angst J, Frye MA. A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression. J Affect Disord. 2014 Jan; 152-154:478-82. Epub 2013 Aug 23.
    View PubMed
  12. Karpyak VM, Winham SJ, Biernacka JM, Cunningham JM, Lewis KA, Geske JR, Colby CL, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Frye MA, Heit JA, Mrazek DA. Association of GATA4 sequence variation with alcohol dependence. Addict Biol. 2014; 19(2):312-5.
  13. Stamm TJ, Lewitzka U, Sauer C, Pilhatsch M, Smolka MN, Koeberle U, Adli M, Ricken R, Scherk H, Frye MA, Juckel G, Assion HJ, Gitlin M, Whybrow PC, Bauer M. Supraphysiologic goses of levothyroxine as adjunctive therapy in bipolar depression: A randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2014; 75(2):162-8.
  14. Bauer M, Glenn T, Alda M, Andreassen OA, Angelopoulos E, Ardau R, Baethge C, Bauer R, Bellivier F, Belmaker RH, Berk M, Bjella TD, Bossini L, Bersudsky Y, Cheung EYW, Conell J, Zompo MD, Dodd S, Etain B, Fagiolini A, Frye MA, Fountoulakis KN, Relationship between sunlight and the age of onset of bipolar disorder: An international multisite study. J Affect Disord. 2014; 167:104-11.
  15. Post RM, Altshuler L, Leverich G, Nolen W, Kupka R, Grunze H, Frye M, Suppes T, McElroy S, Keck P, Rowe M. More stressors prior to and during the course of bipolar illness in patients from the United States compared with the Netherlands and Germany. Psychiatry Res. 2013 Dec 30; 210(3):880-6. Epub 2013 Sep 08.
    View PubMed
  16. Chopra A, Abulseoud OA, Sampson S, Lee KH, Klassen BT, Fields JA, Matsumoto JY, Adams AC, Stoppel CJ, Geske JR, Frye MA. Mood Stability in Parkinson Disease Following Deep Brain Stimulation: A 6-Month Prospective Follow-up Study. Psychosomatics. 2013 Dec 19.
    View PubMed
  17. Kim JP, Min HK, Knight EJ, Duffy PS, Abulseoud OA, Marsh MP, Kelsey K, Blaha CD, Bennet KE, Frye MA, Lee KH. Centromedian-parafascicular deep brain stimulation induces differential functional inhibition of the motor, associative, and limbic circuits in large animals. Biol Psychiatry. 2013 Dec 15; 74(12):917-26. Epub 2013 Aug 30.
    View PubMed
  18. Winham SJ, Cuellar-Barboza AB, Oliveros A, McElroy SL, Crow S, Colby C, Choi DS, Chauhan M, Frye M, Biernacka JM. Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2. Mol Psychiatry. 2013 Dec 10. [Epub ahead of print]
    View PubMed
  19. Hoberg AA, Vickers KS, Ericksen J, Bauer G, Kung S, Stone R, Williams M, Moore MJ, Frye MA. Feasibility evaluation of an interpersonal and social rhythm therapy group delivery model. Arch Psychiatr Nurs. 2013 Dec; 27(6):271-7. Epub 2013 Sep 12.
    View PubMed
  20. Pacchiarotti I, Bond DJ, Baldessarini RJ, Nolen WA, Grunze H, Licht RW, Post RM, Berk M, Goodwin GM, Sachs GS, Tondo L, Findling RL, Youngstrom EA, Tohen M, Undurraga J, Gonzalez-Pinto A, Goldberg JF, Yildiz A, Altshuler LL, Calabrese JR, Mitchell PB, The International Society for Bipolar Disorders (ISBD) task force report on antidepressant use in bipolar disorders. Am J Psychiatry. 2013 Nov 1; 170(11):1249-62.
    View PubMed
  21. Kasasbeh A, Abulseoud OA, Matsumoto JY, Stead SM, Goerss SJ, Klassen BT, Huston J 3rd, Min HK, Lee KH, Frye MA. Lack of differential motor outcome with subthalamic nucleus region stimulation in Parkinson's disease. J Clin Neurosci. 2013 Nov; 20(11):1520-6. Epub 2013 Jul 29.
    View PubMed
  22. McElroy SL, Crow S, Biernacka JM, Winham S, Geske J, Cuellar Barboza AB, Prieto ML, Chauhan M, Seymour LR, Mori N, Frye MA. Clinical phenotype of bipolar disorder with comorbid binge eating disorder. J Affect Disord. 2013 Sep 25; 150(3):981-6. Epub 2013 Jun 03.
    View PubMed
  23. Abulseoud OA, Karpyak VM, Schneekloth T, Hall-Flavin DK, Loukianova LL, Geske JR, Biernacka JM, Mrazek DA, Frye MA. A retrospective study of gender differences in depressive symptoms and risk of relapse in patients with alcohol dependence. Am J Addict. 2013 Sep-Oct; 22(5):437-42. Epub 2013 May 30.
    View PubMed
  24. Karpyak VM, Winham SJ, Preuss UW, Zill P, Cunningham JM, Walker DL, Lewis KA, Geske JR, Colby CL, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Frye MA, Bazov I, Heit JA, Bakalkin G, Mrazek DA, Biernacka JM. Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states. Int J Neuropsychopharmacol. 2013 Jun; 16(5):975-85. Epub 2012 Oct 29.
    View PubMed
  25. Port JD, Rampton KE, Shu Y, Manduca A, Frye MA. Short TE (7) Li-MRS confirms Bi-exponential lithium T2 relaxation in humans and clearly delineates two patient subtypes. J Magn Reson Imaging. 2013 Jun; 37(6):1451-9. Epub 2012 Nov 12.
    View PubMed
  26. Leedahl DD, Cunningham JL, Drake MT, Mundis CB, Kung S, Frye MA, Lapid MI. Hypovitaminosis D in psychiatric inpatients: clinical correlation with depressive symptoms, cognitive impairment, and prescribing practices. Psychosomatics. 2013 May-Jun; 54(3):257-62. Epub 2012 Dec 01.
    View PubMed
  27. Frye MA, Ketter TA, Yang R, Calabrese JR. A double-blind, placebo-controlled, multicenter trial of adjunctive armodafinil for the treatment of major depression associated with bipolar I disorder. Value Health. 2013 May; 16(3):A55-6. Epub 2013 May 03.
    View PubMed
  28. Post RM, Altshuler LL, Leverich GS, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Kupka RW, Grunze H, Rowe M. Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder. J Affect Disord. 2013 May; 147(1-3):288-94. Epub 2013 Jan 18.
    View PubMed
  29. Rasmussen KG, Lineberry TW, Galardy CW, Kung S, Lapid MI, Palmer BA, Ritter MJ, Schak KM, Sola CL, Hanson AJ, Frye MA. Serial infusions of low-dose ketamine for major depression. J Psychopharmacol. 2013 May; 27(5):444-50. Epub 2013 Feb 20.
    View PubMed
  30. Frey BN, Andreazza AC, Houenou J, Jamain S, Goldstein BI, Frye MA, Leboyer M, Berk M, Malhi GS, Lopez-Jaramillo C, Taylor VH, Dodd S, Frangou S, Hall GB, Fernandes BS, Kauer-Sant'Anna M, Yatham LN, Kapczinski F, Young LT. Biomarkers in bipolar disorder: a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force. Aust N Z J Psychiatry. 2013 Apr; 47(4):321-32. Epub 2013 Feb 14.
    View PubMed
  31. Kung S, Alarcon RD, Williams MD, Poppe KA, Jo Moore M, Frye MA. Comparing the Beck Depression Inventory-II (BDI-II) and Patient Health Questionnaire (PHQ-9) depression measures in an integrated mood disorders practice. J Affect Disord. 2013 Mar 5; 145(3):341-3. Epub 2012 Sep 25.
    View PubMed
  32. Abulseoud OA, Gitlin M, Altshuler L, Frye MA. Baseline thyroid indices and the subsequent response to citalopram treatment, a pilot study. Brain Behav. 2013 Mar; 3(2):89-94. Epub 2013 Jan 18.
    View PubMed
  33. Lapid MI, Drake MT, Geske JR, Mundis CB, Hegard TL, Kung S, Frye MA. Hypovitaminosis D in psychogeriatric inpatients. J Nutr Health Aging. 2013 Mar; 17(3):231-4.
    View PubMed
  34. Post RM, Chang K, Frye MA. Paradigm shift: preliminary clinical categorization of ultrahigh risk for childhood bipolar disorder to facilitate studies on prevention. J Clin Psychiatry. 2013 Feb; 74(2):167-9.
    View PubMed
  35. Swann AC, Lafer B, Perugi G, Frye MA, Bauer M, Bahk WM, Scott J, Ha K, Suppes T. Bipolar mixed states: an international society for bipolar disorders task force report of symptom structure, course of illness, and diagnosis. Am J Psychiatry. 2013 Jan 1; 170(1):31-42.
    View PubMed
  36. Biernacka JM, Geske JR, Schneekloth TD, Frye MA, Cunningham JM, Choi DS, Tapp CL, Lewis BR, Drews MS, L Pietrzak T, Colby CL, Hall-Flavin DK, Loukianova LL, Heit JA, Mrazek DA, Karpyak VM. Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C. PLoS One. 2013; 8(3):e58798. Epub 2013 Mar 13.
    View PubMed
  37. Knight EJ, Min HK, Hwang SC, Marsh MP, Paek S, Kim I, Felmlee JP, Abulseoud OA, Bennet KE, Frye MA, Lee KH. Nucleus accumbens deep brain stimulation results in insula and prefrontal activation: a large animal FMRI study. PLoS One. 2013; 8(2):e56640. Epub 2013 Feb 18.
    View PubMed
  38. Hoberg AA, Ponto J, Nelson PJ, Frye MA. Group interpersonal and social rhythm therapy for bipolar depression. Perspect Psychiatr Care. 2013; 49(4):226-34.
  39. Manchia M, Adli M, Akula N, Ardau R, Aubry JM, Backlund L, Banzato CE, Baune BT, Bellivier F, Bengesser S, Biernacka JM, Brichant-Petitjean C, Bui E, Calkin CV, Cheng AT, Chillotti C, Cichon S, Clark S, Czerski PM, Dantas C, Zompo MD, Depaulo JR, Detera-W Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report. PLoS One. 2013; 8(6):e65636. Epub 2013 Jun 19
    View PubMed
  40. Leboyer M, Soreca I, Scott J, Frye M, Henry C, Tamouza R, Kupfer DJ. Can bipolar disorder be viewed as a multi-system inflammatory disease? J Affect Disord. 2012 Dec 1; 141(1):1-10. Epub 2012 Apr 11.
    View PubMed
  41. Chopra A, Tye SJ, Lee KH, Sampson S, Matsumoto J, Adams A, Klassen B, Stead M, Fields JA, Frye MA. Underlying neurobiology and clinical correlates of mania status after subthalamic nucleus deep brain stimulation in Parkinson's disease: a review of the literature. J Neuropsychiatry Clin Neurosci. 2012 Winter; 24(1):102-10.
    View PubMed
  42. Schneekloth TD, Biernacka JM, Hall-Flavin DK, Karpyak VM, Frye MA, Loukianova LL, Stevens SR, Drews MS, Geske JR, Mrazek DA. Alcohol craving as a predictor of relapse. Am J Addict. 2012 Nov; 21 Suppl 1:S20-6.
    View PubMed
  43. Anderson RJ, Frye MA, Abulseoud OA, Lee KH, McGillivray JA, Berk M, Tye SJ. Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action. Neurosci Biobehav Rev. 2012 Sep; 36(8):1920-33. Epub 2012 Jun 18.
    View PubMed
  44. Bauer M, Glenn T, Alda M, Andreassen OA, Ardau R, Bellivier F, Berk M, Bjella TD, Bossini L, Del Zompo M, Dodd S, Fagiolini A, Frye MA, Gonzalez-Pinto A, Henry C, Kapczinski F, Kliwicki S, Konig B, Kunz M, Lafer B, Lopez-Jaramillo C, Manchia M, Marsh W, Impact of sunlight on the age of onset of bipolar disorder. Bipolar Disord. 2012 Sep; 14(6):654-63. Epub 2012 May 21.
    View PubMed
  45. Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Nolen WA, Rowe M, Kupka RW, Grunze H, Goodwin FK. Relationship of prior antidepressant exposure to long-term prospective outcome in bipolar I disorder outpatients. J Clin Psychiatry. 2012 Jul; 73(7):924-30. Epub 2012 Mar 20.
    View PubMed
  46. Hinton DJ, Lee MR, Jacobson TL, Mishra PK, Frye MA, Mrazek DA, Macura SI, Choi DS. Ethanol withdrawal-induced brain metabolites and the pharmacological effects of acamprosate in mice lacking ENT1. Neuropharmacology. 2012 Jun; 62(8):2480-8.
    View PubMed
  47. Chopra A, Kolla BP, Mansukhani MP, Netzel P, Frye MA. Valproate-induced hyperammonemic encephalopathy: an update on risk factors, clinical correlates and management. Gen Hosp Psychiatry. 2012 May-Jun; 34(3):290-8. Epub 2012 Feb 02.
    View PubMed
  48. Malhi GS, Bargh DM, McIntyre R, Gitlin M, Frye MA, Bauer M, Berk M. Balanced efficacy, safety, and tolerability recommendations for the clinical management of bipolar disorder. Bipolar Disord. 2012 May; 14 Suppl 2:1-21.
    View PubMed
  49. Gitlin M, Frye MA. Maintenance therapies in bipolar disorders. Bipolar Disord. 2012 May; 14 Suppl 2:51-65.
    View PubMed
  50. Malhi GS, Bargh DM, Cashman E, Frye MA, Gitlin M. The clinical management of bipolar disorder complexity using a stratified model. Bipolar Disord. 2012 May; 14 Suppl 2:66-89.
    View PubMed
  51. Biernacka JM, McElroy SL, Crow S, Sharp A, Benitez J, Veldic M, Kung S, Cunningham JM, Post RM, Mrazek D, Frye MA. Pharmacogenomics of antidepressant induced mania: a review and meta-analysis of the serotonin transporter gene (5HTTLPR) association. J Affect Disord. 2012 Jan; 136(1-2):e21-9. Epub 2011 Jun 15.
    View PubMed
  52. Li X, Frye MA, Shelton RC. Review of pharmacological treatment in mood disorders and future directions for drug development. Neuropsychopharmacology. 2012 Jan; 37(1):77-101. Epub 2011 Sep 07.
    View PubMed
  53. Lapid MI, Drake MT, Geske JR, Mundis CB, Hegard TL, Kung S, Frye MA. Hypovitaminosis D in psychogeriatric inpatients J Nutr Health Aging. 2012. [Epub ahead of print]
  54. Kolla BP, Schneekloth TD, Biernacka JM, Frye MA, Mansukhani MP, Hall-Flavin DK, Karpyak VM, Loukianova LL, Lesnick TG, Mrazek D. Trazodone and alcohol relapse: a retrospective study following residential treatment. Am J Addict. 2011 Nov-Dec; 20(6):525-9. Epub 2011 Sep 29.
    View PubMed
  55. Frye MA, Ha K, Kanba S, Kato T, McElroy SL, Ozerdem A, Vazquez G, Vieta E. International consensus group on depression prevention in bipolar disorder. J Clin Psychiatry. 2011 Oct; 72(10):1295-310.
    View PubMed
  56. Williams MD, Shah ND, Wagie AE, Wood DL, Frye MA. Direct costs of bipolar disorder versus other chronic conditions: an employer-based health plan analysis. Psychiatr Serv. 2011 Sep; 62(9):1073-8.
    View PubMed
  57. Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes T, Keck PE, McElroy SL, Nolen WA, Kupka R, Grunze H, Walden J, Rowe M. Differential clinical characteristics, medication usage, and treatment response of bipolar disorder in the US versus The Netherlands and Germany. Int Clin Psychopharmacol. 2011 Mar; 26(2):96-106.
    View PubMed
  58. McElroy SL, Frye MA, Hellemann G, Altshuler L, Leverich GS, Suppes T, Keck PE, Nolen WA, Kupka R, Post RM. Prevalence and correlates of eating disorders in 875 patients with bipolar disorder. J Affect Disord. 2011 Feb; 128(3):191-8. Epub 2010 Jul 31.
    View PubMed
  59. Frye MA. Clinical practice. Bipolar disorder--a focus on depression. N Engl J Med. 2011 Jan 6; 364(1):51-9.
    View PubMed
  60. Hall-Flavin DK, Schneekloth TD, Loukianova LL, Karpyak VM, Lesnick TG, Biernacka JM, Mrazek DA, Frye MA. Utilization of residential alcoholism treatment in bipolar disorder. Am J Addict. 2011 Jan-Feb; 20(1):40-4. Epub 2010 Nov 12.
    View PubMed
  61. Shippee ND, Shah ND, Williams MD, Moriarty JP, Frye MA, Ziegenfuss JY. Differences in demographic composition and in work, social, and functional limitations among the populations with unipolar depression and bipolar disorder: results from a nationally representative sample. Health Qual Life Outcomes. 2011; 9:90. Epub 2011 Oct 13.
    View PubMed
  62. Calabrese JR, Ketter TA, Youakim JM, Tiller JM, Yang R, Frye MA. Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder: a randomized, multicenter, double-blind, placebo-controlled, proof-of-concept study. J Clin Psychiatry. 2010 Oct; 71(10):1363-70. Epub 2010 Jul 27.
    View PubMed
  63. Post RM, Altshuler LL, Frye MA, Suppes T, Keck PE Jr, McElroy SL, Leverich GS, Luckenbaugh DA, Rowe M, Pizzarello S, Kupka RW, Grunze H, Nolen WA. Complexity of pharmacologic treatment required for sustained improvement in outpatients with bipolar disorder. J Clin Psychiatry. 2010 Sep; 71(9):1176-86; quiz 1252-3.
    View PubMed
  64. Gitlin MJ, Abulseoud O, Frye MA. Improving the design of maintenance studies for bipolar disorder. Curr Med Res Opin. 2010 Aug; 26(8):1835-42.
    View PubMed
  65. Post RM, Leverich GS, Kupka RW, Keck PE Jr, McElroy SL, Altshuler LL, Frye MA, Luckenbaugh DA, Rowe M, Grunze H, Suppes T, Nolen WA. Early-onset bipolar disorder and treatment delay are risk factors for poor outcome in adulthood. J Clin Psychiatry. 2010 Jul; 71(7):864-72.
    View PubMed
  66. Boykoff N, Schneekloth TD, Hall-Flavin D, Loukianova L, Karpyak VM, Stevens SR, Biernacka JM, Mrazek DA, Frye MA. Gender differences in the relationship between depressive symptoms and cravings in alcoholism. Am J Addict. 2010 Jul-Aug; 19(4):352-6.
    View PubMed
  67. Altshuler LL, Kupka RW, Hellemann G, Frye MA, Sugar CA, McElroy SL, Nolen WA, Grunze H, Leverich GS, Keck PE, Zermeno M, Post RM, Suppes T. Gender and depressive symptoms in 711 patients with bipolar disorder evaluated prospectively in the Stanley Foundation bipolar treatment outcome network. Am J Psychiatry. 2010 Jun; 167(6):708-15. Epub 2010 Mar 15.
    View PubMed
  68. Frye MA. Treatment guidelines for acute manic and mixed episodes of bipolar disorder. Cns Spectrums. 2009 Dec; 14(Suppl 15):8-11.
    View PubMed
  69. Benazzi F, Berk M, Frye MA, Wang W, Barraco A, Tohen M. Olanzapine/fluoxetine combination for the treatment of mixed depression in bipolar I disorder: a post hoc analysis. J Clin Psychiatry. 2009 Oct; 79(10):1424-31.
    View PubMed
  70. Goldberg JF, Calabrese JR, Saville BR, Frye MA, Ketter TA, Suppes T, Post RM, Goodwin FK. Mood stabilization and destabilization during acute and continuation phase treatment for bipolar I disorder with lamotrigine or placebo. J Clin Psychiatry. 2009 Sep; 70(9):1273-80. Epub 2009 Aug 11.
    View PubMed
  71. Frye MA, Yatham L, Ketter TA, Goldberg J, Suppes T, Calabrese JR, Bowden CL, Bourne E, Bahn RS, Adams B. Depressive relapse during lithium treatment associated with increased serum thyroid-stimulating hormone: results from two placebo-controlled bipolar I maintenance studies. Acta Psychiatr Scand. 2009 Jul; 120(1):10-3. Epub 2009 Jan 31.
    View PubMed
  72. Tye SJ, Frye MA, Lee KH. Disrupting disordered neurocircuitry: treating refractory psychiatric illness with neuromodulation. Mayo Clin Proc. 2009 Jun; 84(6):522-32.
    View PubMed
  73. Altshuler LL, Post RM, Hellemann G, Leverich GS, Nolen WA, Frye MA, Keck PE Jr, Kupka RW, Grunze H, McElroy SL, Sugar CA, Suppes T. Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study. J Clin Psychiatry. 2009 Apr; 70(4):450-7. Epub 2009 Apr 07.
    View PubMed
  74. Frye MA, Helleman G, McElroy SL, Altshuler LL, Black DO, Keck PE Jr, Nolen WA, Kupka R, Leverich GS, Grunze H, Mintz J, Post RM, Suppes T. Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression. Am J Psychiatry. 2009 Feb; 166(2):164-72. Epub 2008 Nov 17.
    View PubMed
  75. Kupka R, Frye MA. Diagnosis and treatment of rapid cycling bipolar disorder. In: Yatham LN; Kusumakar V editor. Bipolar disorder: A clinician's guide to treatment management. 2nd Edition. New York: Routledge/Taylor & Francis Group; 2009. p. 45-77.
    View PubMed
  76. McKeon A, Frye MA, Delanty N. The alcohol withdrawal syndrome. J Neurol Neurosurg Psychiatry. 2008 Aug; 79(8):854-62. Epub 2007 Nov 6
    View PubMed
  77. Frye MA. Diagnostic dilemmas and clinical correlates of mixed states in bipolar disorder. J Clin Psychiatry. 2008 May; 69(5):e13.
    View PubMed
  78. Shivakumar G, Bernstein IH, Suppes T, Stanley Foundation Bipolar Network, Keck PE, McElroy SL, Altshuler LL, Frye MA, Nolen WA, Kupka RW, Grunze H, Leverich GS, Mintz J, Post RM. Are bipolar mood symptoms affected by the phase of the menstrual cycle? J Womens Health (Larchmt) 2008 Apr; 17(3):473-8.
    View PubMed
  79. Post RM, Luckenbaugh DA, Leverich GS, Altshuler LL, Frye MA, Suppes T, Keck PE, McElroy SL, Nolen WA, Kupka R, Grunze H, Walden J. Incidence of childhood-onset bipolar illness in the USA and Europe. Br J Psychiatry. 2008 Feb; 192(2):150-1.
    View PubMed
  80. Cardenas J, Frye MA, Marusak SL, Levander EM, Chirichigno JW, Lewis S, Nakelsky S, Hwang S, Mintz J, Altshuler LL. Modal subcomponents of metabolic syndrome in patients with bipolar disorder. J Affect Disord. 2008 Feb; 106(1-2):91-7. Epub 2007 Jul 12.
    View PubMed
  81. Goldberg JF, Bowden CL, Calabrese JR, Ketter TA, Dann RS, Frye MA, Suppes T, Post RM. Six-month prospective life charting of mood symptoms with lamotrigine monotherapy versus placebo in rapid cycling bipolar disorder. Biol Psychiatry. 2008 Jan 1; 63(1):125-30. Epub 2007 Jun 01.
    View PubMed
  82. Hirschfeld RM, Calabrese JR, Frye MA, Lavori PW, Sachs G, Thase ME, Wagner KD. Defining the clinical course of bipolar disorder: response, remission, relapse, recurrence, and roughening. Psychopharmacol Bull. 2008; 40:7-14.
    View PubMed
  83. Abulseoud OA, Hellmann G, Calabrese JR, Verduin ML, Chirichigno JW, McKowen J, Gitlin MJ, Altshuler LL, Frye MA. Sex and bipolar subtype association with self-reported hazardous alcohol consumption in bipolar depression. Journal of Dual Diagnosis. 2008; 4(3):291-302.
    View PubMed
  84. Frye MA, Watzl J, Banakar S, O'Neill J, Mintz J, Davanzo P, Fischer J, Chirichigno JW, Ventura J, Elman S, Tsuang J, Walot I, Thomas MA. Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology. 2007 Dec; 32(12):2490-9. Epub 2007 Apr 11.
    View PubMed
  85. Keck PE Jr, Frye MA, Thase ME. Bipolar depression: best practices for the hospitalized patient. CNS Spectr. 2007 Nov; 12(11 Suppl 19):1-13.
    View PubMed
  86. Suppes T, Kelly DI, Keck PE Jr, McElroy SL, Altshuler LL, Mintz J, Frye MA, Nolen WA, Luckenbaugh DA, Post RM, Leverich GS, Kupka RW, Grunze H. Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network. Int Clin Psychopharmacol. 2007 Nov; 22(6):376-81.
    View PubMed
  87. Levander E, Frye MA, McElroy S, Suppes T, Grunze H, Nolen WA, Kupka R, Keck PE Jr, Leverich GS, Altshuler LL, Hwang S, Mintz J, Post RM. Alcoholism and anxiety in bipolar illness: differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism. J Affect Disord. 2007 Aug; 101(1-3):211-7. Epub 2007 Jan 23.
    View PubMed
  88. Frye MA, Grunze H, Suppes T, McElroy SL, Keck PE Jr, Walden J, Leverich GS, Altshuler LL, Nakelsky S, Hwang S, Mintz J, Post RM. A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression. Am J Psychiatry. 2007 Aug; 164(8):1242-9.
    View PubMed
  89. McDermott BE, Quanbeck CD, Frye MA. Comorbid substance use disorder in women with bipolar disorder associated with criminal arrest. Bipolar Disord. 2007 Aug; 9(5):536-40.
    View PubMed
  90. Kupka RW, Altshuler LL, Nolen WA, Suppes T, Luckenbaugh DA, Leverich GS, Frye MA, Keck PE Jr, McElroy SL, Grunze H, Post RM. Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder. Bipolar Disord. 2007 Aug; 9(5):531-5.
    View PubMed
  91. McElroy SL, Suppes T, Frye MA, Altshuler LL, Stanford K, Martens B, Leverich GS, Post RM, Keck PE Jr. Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial. J Affect Disord. 2007 Aug; 101(1-3):275-81. Epub 2007 Jan 16.
    View PubMed
  92. McElroy SL, Frye MA, Altshuler LL, Suppes T, Hellemann G, Black D, Mintz J, Kupka R, Nolen W, Leverich GS, Denicoff KD, Post RM, Keck PE Jr. A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders. Bipolar Disord. 2007 Jun; 9(4):426-34.
    View PubMed
  93. Abulseoud O, Sane N, Cozzolino A, Kiriakos L, Mehra V, Gitlin M, Masseling S, Whybrow P, Altshuler LL, Mintz J, Frye MA. Free T4 index and clinical outcome in patients with depression. J Affect Disord. 2007 Jun; 100(1-3):271-7. Epub 2006 Nov 22.
    View PubMed
  94. Leverich GS, Post RM, Keck PE Jr, Altshuler LL, Frye MA, Kupka RW, Nolen WA, Suppes T, McElroy SL, Grunze H, Denicoff K, Moravec MK, Luckenbaugh D. The poor prognosis of childhood-onset bipolar disorder. J Pediatr. 2007 May; 150(5):485-90.
    View PubMed
  95. Nolen WA, Kupka RW, Hellemann G, Frye MA, Altshuler LL, Leverich GS, Suppes T, Keck PE Jr, McElroy S, Grunze H, Mintz J, Post RM. Tranylcypromine vs. lamotrigine in the treatment of refractory bipolar depression: a failed but clinically useful study. Acta Psychiatr Scand. 2007 May; 115(5):360-5.
    View PubMed
  96. Frye MA, Thomas MA, Yue K, Binesh N, Davanzo P, Ventura J, O'Neill J, Guze B, Curran JG, Mintz J. Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: a study using 3-Tesla proton magnetic resonance spectroscopy. Psychiatry Res. 2007 Apr 15; 154(3):259-65. Epub 2007 Mar 07.
    View PubMed
  97. Frye MA, Tsai GE, Huggins T, Coyle JT, Post RM. Low cerebrospinal fluid glutamate and glycine in refractory affective disorder. Biol Psychiatry. 2007 Jan 15; 61(2):162-6. Epub 2006 Jun 02.
    View PubMed
  98. Frye MA, Thomas MA, Yue K, Binesh N, Davanzo P, Ventura J, O’Neil J, Barry Guze B, Curran JG, Mintz J. Reduced Basal Ganglia [NAA] and NAA/Cr in Mania: A 3T 1H MRS Study. J Psychiatric Research Neuroimaging. 2007; 154:259-65.
  99. Fan AH, Frye MA, Masseling SJ, Hwang S, Cozzolino A, Kiriakos L, Mintz J, Sane N, Gitlin MJ, Altshuler L. Increased suicidality in mania complicated by alcoholism. Psychiatry. 2007; 4:34-9.
    View PubMed
  100. Post RM, Altshuler LL, Frye MA, Suppes T, McElroy S, Keck PE Jr, Leverich GS, Kupka R, Nolen WA, Grunze H. New findings from the Bipolar Collaborative Network: clinical implications for therapeutics. Curr Psychiatry Rep. 2006 Dec; 8(6):489-97.
    View PubMed
  101. Frye MA, Salloum IM. Bipolar disorder and comorbid alcoholism: prevalence rate and treatment considerations. Bipolar Disord. 2006 Dec; 8(6):677-85.
    View PubMed
  102. Keck PE Jr, Mintz J, McElroy SL, Freeman MP, Suppes T, Frye MA, Altshuler LL, Kupka R, Nolen WA, Leverich GS, Denicoff KD, Grunze H, Duan N, Post RM. Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder. Biol Psychiatry. 2006 Nov 1; 60(9):1020-2. Epub 2006 Jun 30.
    View PubMed
  103. Frye MA, Yatham LN, Calabrese JR, Bowden CL, Ketter TA, Suppes T, Adams BE, Thompson TR. Incidence and time course of subsyndromal symptoms in patients with bipolar I disorder: an evaluation of 2 placebo-controlled maintenance trials. J Clin Psychiatry. 2006 Nov; 67(11):1721-8.
    View PubMed
  104. Altshuler LL, Post RM, Black DO, Keck PE Jr, Nolen WA, Frye MA, Suppes T, Grunze H, Kupka RW, Leverich GS, McElroy SL, Walden J, Mintz J. Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study. J Clin Psychiatry. 2006 Oct; 67(10):1551-60.
    View PubMed
  105. Frye MA, Calabrese JR, Reed ML, Hirschfeld RM. Healthcare resource utilization in bipolar depression compared with unipolar depression: results of a United States population-based study. CNS Spectr. 2006 Sep; 11(9):704-10; quiz 719.
    View PubMed
  106. Brook M, Hilty DM, Liu W, Hu R, Frye MA. Discharge against medical advice from inpatient psychiatric treatment: a literature review. Psychiatr Serv. 2006 Aug; 57(8):1192-8.
    View PubMed
  107. Post RM, Altshuler LL, Leverich GS, Frye MA, Nolen WA, Kupka RW, Suppes T, McElroy S, Keck PE, Denicoff KD, Grunze H, Walden J, Kitchen CM, Mintz J. Mood switch in bipolar depression: comparison of adjunctive venlafaxine, bupropion and sertraline. Br J Psychiatry. 2006 Aug; 189:124-31.
    View PubMed
  108. Calabrese JR, Goldberg JF, Ketter TA, Suppes T, Frye M, White R, DeVeaugh-Geiss A, Thompson TR. Recurrence in bipolar I disorder: a post hoc analysis excluding relapses in two double-blind maintenance studies. Biol Psychiatry. 2006 Jun 1; 59(11):1061-4.
    View PubMed
  109. Altshuler LL, Suppes T, Black DO, Nolen WA, Leverich G, Keck PE Jr, Frye MA, Kupka R, McElroy SL, Grunze H, Kitchen CM, Post R. Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants. Am J Psychiatry. 2006 Feb; 163(2):313-5.
    View PubMed
  110. Leverich GS, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Kupka RW, Denicoff KD, Nolen WA, Grunze H, Martinez MI, Post RM. Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers. Am J Psychiatry. 2006 Feb; 163(2):232-9.
    View PubMed
  111. Calabrese JR, Muzina DJ, Kemp DE, Sachs GS, Frye MA, Thompson TR, Klingman D, Reed ML, Hirschfeld RM. Predictors of bipolar disorder risk among patients currently treated for major depression. MedGenMed. 2006; 8(3):38. Epub 2006 Aug 15.
    View PubMed
  112. Quanbeck CD, McDermott BE, Frye MA. Clinical and legal characteristics of inmates with bipolar disorder. Curr Psychiatry Rep. 2005 Dec; 7(6):478-84.
    View PubMed
  113. Frye MA, Calabrese JR, Reed ML, Wagner KD, Lewis L, McNulty J, Hirschfeld RM. Use of health care services among persons who screen positive for bipolar disorder. Psychiatr Serv. 2005 Dec; 56(12):1529-33.
    View PubMed
  114. Rasgon NL, Reynolds MF, Elman S, Saad M, Frye MA, Bauer M, Altshuler LL. Longitudinal evaluation of reproductive function in women treated for bipolar disorder. J Affect Disord. 2005 Dec; 89(1-3):217-25. Epub 2005 Sep 19.
    View PubMed
  115. Suppes T, Mintz J, McElroy SL, Altshuler LL, Kupka RW, Frye MA, Keck PE Jr, Nolen WA, Leverich GS, Grunze H, Rush AJ, Post RM. Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon. Arch Gen Psychiatry. 2005 Oct; 62(10):1089-96.
    View PubMed
  116. Quanbeck CD, Stone DC, McDermott BE, Boone K, Scott CL, Frye MA. Relationship between criminal arrest and community treatment history among patients with bipolar disorder. Psychiatr Serv. 2005 Jul; 56(7):847-52.
    View PubMed
  117. Kupka RW, Luckenbaugh DA, Post RM, Suppes T, Altshuler LL, Keck PE Jr, Frye MA, Denicoff KD, Grunze H, Leverich GS, McElroy SL, Walden J, Nolen WA. Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients. Am J Psychiatry. 2005 Jul; 162(7):1273-80.
    View PubMed
  118. Rasgon NL, Altshuler LL, Fairbanks L, Elman S, Bitran J, Labarca R, Saad M, Kupka R, Nolen WA, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Leverich G, Grunze H, Walden J, Post R, Mintz J. Reproductive function and risk for PCOS in women treated for bipolar disorder. Bipolar Disord. 2005 Jun; 7(3):246-59.
    View PubMed
  119. McElroy SL, Suppes T, Keck PE Jr, Black D, Frye MA, Altshuler LL, Nolen WA, Kupka RW, Leverich GS, Walden J, Grunze H, Post RM. Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial. J Clin Psychiatry. 2005 May; 66(5):617-24.
    View PubMed
  120. Bauer M, London ED, Rasgon N, Berman SM, Frye MA, Altshuler LL, Mandelkern MA, Bramen J, Voytek B, Woods R, Mazziotta JC, Whybrow PC. Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar depression. Mol Psychiatry. 2005 May; 10(5):456-69.
    View PubMed
  121. Post RM, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Leverich GS, Kupka R, Nolen WA, Luckenbaugh DA, Walden J, Grunze H. Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder. J Clin Psychiatry. 2005 Mar; 66(3):370-4.
    View PubMed
  122. Calabrese JR, Hirschfeld RM, Frye MA, Reed ML. Impact of depressive symptoms compared with manic symptoms in bipolar disorder: results of a U.S. community-based sample. J Clin Psychiatry. 2004 Nov; 65(11):1499-504.
    View PubMed
  123. Gitlin M, Altshuler LL, Frye MA, Suri R, Huynh EL, Fairbanks L, Bauer M, Korenman S. Peripheral thyroid hormones and response to selective serotonin reuptake inhibitors. J Psychiatry Neurosci. 2004 Sep; 29(5):383-6.
    View PubMed
  124. State RC, Frye MA, Altshuler LL, Strober M, DeAntonio M, Hwang S, Mintz J. Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania. J Clin Psychiatry. 2004 Aug; 65(8):1057-63.
    View PubMed
  125. Nolen WA, Luckenbaugh DA, Altshuler LL, Suppes T, McElroy SL, Frye MA, Kupka RW, Keck PE Jr, Leverich GS, Post RM. Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network. Am J Psychiatry. 2004 Aug; 161(8):1447-54.
    View PubMed
  126. Quanbeck CD, Stone DC, Scott CL, McDermott BE, Altshuler LL, Frye MA. Clinical and legal correlates of inmates with bipolar disorder at time of criminal arrest. J Clin Psychiatry. 2004 Feb; 65(2):198-203.
    View PubMed
  127. Frye MA, Gitlin MJ, Altshuler LL. Unmet needs in bipolar depression. Depress Anxiety. 2004; 19(4):199-208.
    View PubMed
  128. Post RM, Leverich GS, Nolen WA, Kupka RW, Altshuler LL, Frye MA, Suppes T, McElroy S, Keck P, Grunze H, Walden J, Stanley Foundation Bipolar Network. A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network. Bipolar Disord. 2003 Dec; 5(6):396-406.
    View PubMed
  129. Post RM, Leverich GS, Altshuler LL, Frye MA, Suppes TM, Keck PE Jr, McElroy SL, Kupka R, Nolen WA, Grunze H, Walden J. An overview of recent findings of the Stanley Foundation Bipolar Network (Part I). Bipolar Disord. 2003 Oct; 5(5):310-9.
    View PubMed
  130. Altshuler L, Suppes T, Black D, Nolen WA, Keck PE Jr, Frye MA, McElroy S, Kupka R, Grunze H, Walden J, Leverich G, Denicoff K, Luckenbaugh D, Post R. Impact of antidepressant discontinuation after acute bipolar depression remission on rates of depressive relapse at 1-year follow-up. Am J Psychiatry. 2003 Jul; 160(7):1252-62.
    View PubMed
  131. Quanbeck C, Frye M, Altshuler L. Mania and the law in California: understanding the criminalization of the mentally ill. Am J Psychiatry. 2003 Jul; 160(7):1245-50.
    View PubMed
  132. Keck PE Jr, McElroy SL, Havens JR, Altshuler LL, Nolen WA, Frye MA, Suppes T, Denicoff KD, Kupka R, Leverich GS, Rush AJ, Post RM. Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness. Compr Psychiatry. 2003 Jul-Aug; 44(4):263-9.
    View PubMed
  133. Tohen M, Ketter TA, Zarate CA, Suppes T, Frye M, Altshuler L, Zajecka J, Schuh LM, Risser RC, Brown E, Baker RW. Olanzapine versus divalproex sodium for the treatment of acute mania and maintenance of remission: a 47-week study. Am J Psychiatry. 2003 Jul; 160(7):1263-71.
    View PubMed
  134. Bertolino A, Frye M, Callicott JH, Mattay VS, Rakow R, Shelton-Repella J, Post R, Weinberger DR. Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging. Biol Psychiatry. 2003 May 15; 53(10):906-13.
    View PubMed
  135. Leverich GS, Altshuler LL, Frye MA, Suppes T, Keck PE Jr, McElroy SL, Denicoff KD, Obrocea G, Nolen WA, Kupka R, Walden J, Grunze H, Perez S, Luckenbaugh DA, Post RM. Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network. J Clin Psychiatry. 2003 May; 64(5):506-15.
    View PubMed
  136. Frye MA, Altshuler LL, McElroy SL, Suppes T, Keck PE, Denicoff K, Nolen WA, Kupka R, Leverich GS, Pollio C, Grunze H, Walden J, Post RM. Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder. Am J Psychiatry. 2003 May; 160(5):883-9.
    View PubMed
  137. Altshuler LL, Frye MA, Gitlin MJ. Acceleration and augmentation strategies for treating bipolar depression. Biol Psychiatry. 2003 Apr 15; 53(8):691-700.
    View PubMed
  138. Frye MA, Gitlin MJ, Altshuler LL. Treating acute mania. J Fam Pract. 2003 Mar; Suppl:S10-3.
    View PubMed
  139. Frye MA, Pazzaglia PJ, George MS, Luckenbaugh DA, Vanderham E, Davis CL, Rubinow DR, Post RM. Low CSF somatostatin associated with response to nimodipine in patents with affective illness. Biol Psychiatry. 2003 Jan 15; 53(2):180-3.
    View PubMed
  140. Hirschfeld RM, Calabrese JR, Weissman MM, Reed M, Davies MA, Frye MA, Keck PE Jr, Lewis L, McElroy SL, McNulty JP, Wagner KD. Screening for bipolar disorder in the community. J Clin Psychiatry. 2003 Jan; 64(1):53-9.
    View PubMed
  141. Hirschfeld RM, Holzer C, Calabrese JR, Weissman M, Reed M, Davies M, Frye MA, Keck P, McElroy S, Lewis L, Tierce J, Wagner KD, Hazard E. Validity of the mood disorder questionnaire: a general population study. Am J Psychiatry. 2003 Jan; 160(1):178-80.
    View PubMed
  142. Calabrese JR, Sullivan JR, Bowden CL, Suppes T, Goldberg JF, Sachs GS, Shelton MD, Goodwin FK, Frye MA, Kusumakar V. Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management. J Clin Psychiatry. 2002 Nov; 63(11):1012-9.
    View PubMed
  143. Altshuler LL, Gitlin MJ, Mintz J, Leight KL, Frye MA. Subsyndromal depression is associated with functional impairment in patients with bipolar disorder. J Clin Psychiatry. 2002 Sep; 63(9):807-11.
    View PubMed
  144. State RC, Altshuler LL, Frye MA. Mania and attention deficit hyperactivity disorder in a prepubertal child: diagnostic and treatment challenges. Am J Psychiatry. 2002 Jun; 159(6):918-25.
    View PubMed
  145. Li X, Ketter TA, Frye MA. Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders? J Affect Disord. 2002 May; 69(1-3):1-14.
    View PubMed
  146. McElroy SL, Frye MA, Suppes T, Dhavale D, Keck PE Jr, Leverich GS, Altshuler L, Denicoff KD, Nolen WA, Kupka R, Grunze H, Walden J, Post RM. Correlates of overweight and obesity in 644 patients with bipolar disorder. J Clin Psychiatry. 2002 Mar; 63(3):207-13.
    View PubMed
  147. Post RM, Altshuler LL, Frye MA, Suppes T, Rush AJ, Keck PE Jr, McElroy SL, Denicoff KD, Leverich GS, Kupka R, Nolen WA. Rate of switch in bipolar patients prospectively treated with second-generation antidepressants as augmentation to mood stabilizers. Bipolar Disord. 2001 Oct; 3(5):259-65.
    View PubMed
  148. Altshuler LL, Bauer M, Frye MA, Gitlin MJ, Mintz J, Szuba MP, Leight KL, Whybrow PC. Does thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature. Am J Psychiatry. 2001 Oct; 158(10):1617-22.
    View PubMed
  149. Kupka RW, Nolen WA, Altshuler LL, Denicoff KD, Frye MA, Leverich GS, Keck PE Jr, McElroy SL, Rush AJ, Suppes T, Post RM. The Stanley Foundation Bipolar Network. 2. Preliminary summary of demographics, course of illness and response to novel treatments. Br J Psychiatry Suppl. 2001 Jun; 41:s177-83.
    View PubMed
  150. Post RM, Nolen WA, Kupka RW, Denicoff KD, Leverich GS, Keck PE Jr, McElroy SL, Rush AJ, Suppes T, Altshuler LL, Frye MA, Grunze H, Walden J. The Stanley Foundation Bipolar Network. I. Rationale and methods. Br J Psychiatry Suppl. 2001 Jun; 41:s169-76.
    View PubMed
  151. McElroy SL, Altshuler LL, Suppes T, Keck PE Jr, Frye MA, Denicoff KD, Nolen WA, Kupka RW, Leverich GS, Rochussen JR, Rush AJ, Post RM. Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry. 2001 Mar; 158(3):420-6.
    View PubMed
  152. Post RM, Frye MA, Denicoff KD, Leverich GS, Dunn RT, Osuch EA, Speer AM, Obrocea G, Jajodia K. Emerging trends in the treatment of rapid cycling bipolar disorder: a selected review. Bipolar Disord. 2000 Dec; 2(4):305-15.
    View PubMed
  153. Frye MA, Ketter TA, Kimbrell TA, Dunn RT, Speer AM, Osuch EA, Luckenbaugh DA, Cora-Ocatelli G, Leverich GS, Post RM. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol. 2000 Dec; 20(6):607-14.
    View PubMed
  154. McElroy SL, Suppes T, Keck PE, Frye MA, Denicoff KD, Altshuler LL, Brown ES, Nolen WA, Kupka RW, Rochussen J, Leverich GS, Post RM. Open-label adjunctive topiramate in the treatment of bipolar disorders. Biol Psychiatry. 2000 Jun 15; 47(12):1025-33.
    View PubMed
  155. Vawter MP, Frye MA, Hemperly JJ, VanderPutten DM, Usen N, Doherty P, Saffell JL, Issa F, Post RM, Wyatt RJ, Freed WJ. Elevated concentration of N-CAM VASE isoforms in schizophrenia. J Psychiatr Res. 2000 Jan-Feb; 34(1):25-34.
    View PubMed
  156. Frye MA, Ketter TA, Leverich GS, Huggins T, Lantz C, Denicoff KD, Post RM. The increasing use of polypharmacotherapy for refractory mood disorders: 22 years of study. J Clin Psychiatry. 2000 Jan; 61(1):9-15.
    View PubMed
  157. Frye MA, Denicoff KD, Bryan AL, Smith-Jackson EE, Ali SO, Luckenbaugh D, Leverich GS, Post RM. Association between lower serum free T4 and greater mood instability and depression in lithium-maintained bipolar patients. Am J Psychiatry. 1999 Dec; 156(12):1909-14.
    View PubMed
  158. Altshuler LL, Keck PE Jr, McElroy SL, Suppes T, Brown ES, Denicoff K, Frye M, Gitlin M, Hwang S, Goodman R, Leverich G, Nolen W, Kupka R, Post R. Gabapentin in the acute treatment of refractory bipolar disorder. Bipolar Disord. 1999 Sep; 1(1):61-5.
    View PubMed
  159. Goldstein TR, Frye MA, Denicoff KD, Smith-Jackson E, Leverich GS, Bryan AL, Ali SO, Post RM. Antidepressant discontinuation-related mania: critical prospective observation and theoretical implications in bipolar disorder. J Clin Psychiatry. 1999 Aug; 60(8):563-7; quiz 568-9.
    View PubMed
  160. Ketter TA, Frye MA, Cora-Locatelli G, Kimbrell TA, Post RM. Metabolism and excretion of mood stabilizers and new anticonvulsants. Cell Mol Neurobiol. 1999 Aug; 19(4):511-32.
    View PubMed
  161. Frye MA, Dunn RT, Gary KA, Kimbrell TA, Callahan AM, Luckenbaugh DA, Cora-Locatelli G, Vanderham E, Winokur A, Post RM. Lack of correlation between cerebrospinal fluid thyrotropin-releasing hormone (TRH) and TRH-stimulated thyroid-stimulating hormone in patients with depression. Biol Psychiatry. 1999 Apr 15; 45(8):1049-52.
    View PubMed
  162. Little JT, Ketter TA, Mathe AA, Frye MA, Luckenbaugh D, Post RM. Venlafaxine but not bupropion decreases cerebrospinal fluid 5-hydroxyindoleacetic acid in unipolar depression. Biol Psychiatry. 1999 Feb 1; 45(3):285-9.
    View PubMed
  163. Frye MA, Kimbrell TA, Dunn RT, Piscitelli S, Grothe D, Vanderham E, Cora-Locatelli G, Post RM, Ketter TA. Gabapentin does not alter single-dose lithium pharmacokinetics. J Clin Psychopharmacol. 1998 Dec; 18(6):461-4.
    View PubMed
  164. Pazzaglia PJ, Post RM, Ketter TA, Callahan AM, Marangell LB, Frye MA, George MS, Kimbrell TA, Leverich GS, Cora-Locatelli G, Luckenbaugh D. Nimodipine monotherapy and carbamazepine augmentation in patients with refractory recurrent affective illness. J Clin Psychopharmacol. 1998 Oct; 18(5):404-13.
    View PubMed
  165. Post RM, Denicoff KD, Frye MA, Dunn RT, Leverich GS, Osuch E, Speer A. A history of the use of anticonvulsants as mood stabilizers in the last two decades of the 20th century. Neuropsychobiology. 1998 Oct; 38(3):152-66.
    View PubMed
  166. Post RM, Frye MA, Denicoff KD, Leverich GS, Kimbrell TA, Dunn RT. Beyond lithium in the treatment of bipolar illness. Neuropsychopharmacology. 1998 Sep; 19(3):206-19.
    View PubMed
  167. Dunn RT, Frye MS, Kimbrell TA, Denicoff KD, Leverich GS, Post RM. The efficacy and use of anticonvulsants in mood disorders. Clin Neuropharmacol. 1998 Jul-Aug; 21(4):215-35.
    View PubMed
  168. McElroy SL, Frye M, Denicoff K, Altshuler L, Nolen W, Kupka R, Suppes T, Keck PE Jr, Leverich GS, Kmetz GF, Post RM. Olanzapine in treatment-resistant bipolar disorder. J Affect Disord. 1998 May; 49(2):119-22.
    View PubMed
  169. Parekh PI, Ketter TA, Altshuler L, Frye MA, Callahan A, Marangell L, Post RM. Relationships between thyroid hormone and antidepressant responses to total sleep deprivation in mood disorder patients. Biol Psychiatry. 1998 Mar 1; 43(5):392-4.
    View PubMed
  170. Bonds C, Frye MA, Coudreaut MF, Cunningham M, Spearing M, McGuire M, Guze B. Cost reduction with maintenance ECT in refractory bipolar disorder. J ECT. 1998 Mar; 14(1):36-41.
    View PubMed
  171. Frye MA, Ketter TA, Altshuler LL, Denicoff K, Dunn RT, Kimbrell TA, Cora-Locatelli G, Post RM. Clozapine in bipolar disorder: treatment implications for other atypical antipsychotics. J Affect Disord. 1998 Mar; 48(2-3):91-104.
    View PubMed
  172. Goldberg JF, Altshuler LL, Frye MA, Keck PE. The pharmacoeconomics of treating bipolar illness with divalproex sodium. Dir Psychiatry. 1998; 18:113-28.
  173. Post RM, Kramlinger KG, Joffe RT, Roy-Byrne PP, Rosoff A, Frye MA, Huggins T. Rapid cycling bipolar affective disorder: lack of relation to hypothyroidism. Psychiatry Res. 1997 Aug 29; 72(1):1-7.
    View PubMed
  174. Callahan AM, Frye MA, Marangell LB, George MS, Ketter TA, L'Herrou T, Post RM. Comparative antidepressant effects of intravenous and intrathecal thyrotropin-releasing hormone: confounding effects of tolerance and implications for therapeutics. Biol Psychiatry. 1997 Feb 1; 41(3):264-72.
    View PubMed
  175. Frye MA, Altshuler LL. Selection of initial treatment for bipolar disorder, manic phase. Mod Probl Pharmacopsychiatry. 1997; 25:88-113.
    View PubMed
  176. Post RM, Denicoff KD, Frye MA, Leverich GS. Algorithms for bipolar mania. Mod Probl Pharmacopsychiatry. 1997; 25:114-45.
    View PubMed
  177. Post RM, Leverich GS, Denicoff KD, Frye MA, Kimbrell TA, Dunn R. Alternative approaches to refractory depression in bipolar illness. Depress Anxiety. 1997; 5(4):175-89.
    View PubMed
  178. Post RM, Weiss SRR, Ketter TA, Denicoff KD, George MS, Frye MA, Leverich GR. The kindling model: implications for the etiology and treatment of mood disorders. Current Review Mood & Anxiety Disorders. 1997; 1:113-26.
  179. Post RM, Denicoff KD, Leverich GS, Frye MA. Drug-induced switching in bipolar disorder: prevention and management. CNS Drugs. 1997; 8:352-65.
  180. Post RM, Ketter TA, Denicoff K, Pazzaglia PJ, Leverich GS, Marangell LB, Callahan AM, George MS, Frye MA. The place of anticonvulsant therapy in bipolar illness. Psychopharmacology (Berl) 1996 Nov; 128(2):115-29.
    View PubMed
  181. Poltorak M, Frye MA, Wright R, Hemperly JJ, George MS, Pazzaglia PJ, Jerrels SA, Post RM, Freed WJ. Increased neural cell adhesion molecule in the CSF of patients with mood disorder. J Neurochem. 1996 Apr; 66(4):1532-8.
    View PubMed
  182. Frye MA, Altshuler LL, Szuba MP, Finch NN, Mintz J. The relationship between antimanic agent for treatment of classic or dysphoric mania and length of hospital stay. J Clin Psychiatry. 1996 Jan; 57(1):17-21.
    View PubMed
  183. Post RM, Ketter TA, Pazzaglia PJ, Denicoff K, George MS, Callahan A, Leverich G, Frye M. Rational polypharmacy in the bipolar affective disorders. Epilepsy Res Suppl. 1996; 11:153-80.
    View PubMed
  184. Post RM, Weiss SR, Smith M, Rosen J, Frye M. Stress, conditioning, and the temporal aspects of affective disorders. Ann N Y Acad Sci. 1995 Dec 29; 771:677-96.
    View PubMed
  185. Frye MA, Coudreaut MF, Hakeman SM, Shah BG, Strouse TB, Skotzko CE. Continuous droperidol infusion for management of agitated delirium in an intensive care unit. Psychosomatics. 1995 May-Jun; 36(3):301-5.
    View PubMed
  186. Coudreaut MF, Frye MA, Pynoos R. Civil unrest and exacerbation of psychiatric symptoms: a case series. J Nerv Ment Dis. 1995 Feb; 183(2):109-11.
    View PubMed
  187. Frye MA, Melton LJ 3rd, Bryant SC, Fitzpatrick LA, Wahner HW, Schwartz RS, Riggs BL. Osteoporosis and calcification of the aorta. Bone Miner. 1992 Nov; 19(2):185-94.
    View PubMed
  188. Melton LJ 3rd, Kan SH, Frye MA, Wahner HW, O'Fallon WM, Riggs BL. Epidemiology of vertebral fractures in women. Am J Epidemiol. 1989 May; 129(5):1000-11.
    View PubMed