Publications

  1. Liu M, Ingle JN, Fridley BL, Buzdar AU, Robson ME, Kubo M, Wang L, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Goetz MP, Northfelt DW, Perez EA, Williard CV, Schaid DJ, Nakamura Y, Weinshilboum RM. TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression. Mol Endocrinol. 2013 Apr; 27(4):657-70. Epub 2013 Mar 21. 2311991
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  2. Ellsworth KA, Moon I, Eckloff BW, Fridley BL, Jenkins GD, Batzler A, Biernacka JM, Abo R, Brisbin A, Ji Y, Hebbring S, Wieben ED, Mrazek DA, Weinshilboum RM, Wang L. FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder. Pharmacogenet Genomics. 2013 Mar; 23(3):156-66. 2297914
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  3. Chalise P, Batzler A, Abo R, Wang L, Fridley BL. Simultaneous analysis of multiple data types in pharmacogenomic studies using weighted sparse canonical correlation analysis. OMICS. 2012 Jul-Aug; 16(7-8):363-73. Epub 2012 Jun 26. 2262078
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  4. Luo K, Zhang H, Wang L, Yuan J, Lou Z. Sumoylation of MDC1 is important for proper DNA damage response. EMBO J. 2012 Jun 29; 31(13):3008-19 Epub 2012 May 25. 2247673
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  5. Fridley BL, Lund S, Jenkins GD, Wang L. A Bayesian integrative genomic model for pathway analysis of complex traits. Genet Epidemiol. 2012 May; 36(4):352-9. Epub 2012 Mar 28. 2235462
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  6. Biernacka JM, Jenkins GD, Wang L, Moyer AM, Fridley BL. Use of the gamma method for self-contained gene-set analysis of SNP data. Eur J Hum Genet. 2012 May; 20(5):565-71. Epub 2011 Dec 14. 2210799
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  7. Li L, Schaid DJ, Fridley BL, Kalari KR, Jenkins GD, Abo RP, Batzler A, Moon I, Pelleymounter L, Eckloff BW, Wieben ED, Sun Z, Yang P, Wang L. Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer. Pharmacogenet Genomics. 2012 Feb; 22(2):105-16. 2211867
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  8. Innocenti F, Owzar K, Cox NL, Evans P, Kubo M, Zembutsu H, Jiang C, Hollis D, Mushiroda T, Li L, Friedman P, Wang L, Glubb D, Hurwitz H, Giacomini KM, McLeod HL, Goldberg RM, Schilsky RL, Kindler HL, Nakamura Y, Ratain MJ. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. Clin Cancer Res. 2012 Jan 15; 18(2):577-84. Epub 2011 Dec 05. 2216501
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  9. Niu N, Schaid DJ, Abo RP, Kalari K, Fridley BL, Feng Q, Jenkins G, Batzler A, Brisbin AG, Cunningham JM, Li L, Sun Z, Yang P, Wang L. Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study. BMC Cancer. 2012; 12:422. Epub 2012 Sep 24. 2304043
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  10. Liu M, Wang L, Bongartz T, Hawse JR, Markovic SN, Schaid DJ, Mushiroda T, Kubo M, Nakamura Y, Kamatani N, Goss PE, Ingle JN, Weinshilboum RM. Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression. Breast Cancer Res. 2012; 14(2):R41. Epub 2012 Mar 09. 2236757
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  11. Breheny P, Chalise P, Batzler A, Wang L, Fridley BL. Genetic association studies of copy-number variation: should assignment of copy number states precede testing? PLoS One. 2012; 7(4):e34262. Epub 2012 Apr 06. 2242400
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  12. Hou J, Wang L. FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer. PLoS One. 2012; 7(5):e36252. Epub 2012 May 09. 2246667
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  13. Abo R, Jenkins GD, Wang L, Fridley BL. Identifying the genetic variation of gene expression using gene sets: application of novel gene Set eQTL approach to PharmGKB and KEGG. PLoS One. 2012; 7(8):e43301. Epub 2012 Aug 14. 2264923
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  14. Brisbin A, Jenkins GD, Ellsworth KA, Wang L, Fridley BL. Localization of association signal from risk and protective variants in sequencing studies. Front Genet. 2012; 3:173. Epub 2012 Sep 06. 2270055
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  15. Fridley BL, Batzler A, Li L, Li F, Matimba A, Jenkins GD, Ji Y, Wang L, Weinshilboum RM. Gene set analysis of purine and pyrimidine antimetabolites cancer therapies. Pharmacogenet Genomics. 2011 Nov; 21(11):701-12. 2185920
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  16. Tan XL, Moyer AM, Fridley BL, Schaid DJ, Niu N, Batzler AJ, Jenkins GD, Abo RP, Li L, Cunningham JM, Sun Z, Yang P, Wang L. Genetic variation predicting cisplatin cytotoxicity associated with overall survival in lung cancer patients receiving platinum-based chemotherapy. Clin Cancer Res. 2011 Sep 1; 17(17):5801-11. Epub 2011 Jul 20. 2187876
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  17. Wang L. FKBP51 regulation of AKT/protein kinase B phosphorylation. Curr Opin Pharmacol. 2011 Aug; 11(4):360-4. Epub 2011 Apr 15. 2160195
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  18. Wu TY, Fridley BL, Jenkins GD, Batzler A, Wang L, Weinshilboum RM. Mycophenolic acid response biomarkers: a cell line model system-based genome-wide screen. Int Immunopharmacol. 2011 Aug; 11(8):1057-64. Epub 2011 Mar 23. 2185345
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  19. Li Y, Sun Z, Cunningham JM, Aubry MC, Wampfler JA, Croghan GA, Johnson C, Wu D, Aakre JA, Molina J, Wang L, Pankratz VS, Yang P. Genetic variations in multiple drug action pathways and survival in advanced stage non-small cell lung cancer treated with chemotherapy. Clin Cancer Res. 2011 Jun 1; 17(11):3830-40. 2168509
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  20. Wang L, McLeod HL, Weinshilboum RM. Genomics and drug response. N Engl J Med. 2011 Mar 24; 364(12):1144-53. 2155520
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  21. Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature. 2011 Feb 3; 470(7332):124-8. 2147480
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  22. Rudin D, Li L, Niu N, Kalari KR, Gilbert JA, Ames MM, Wang L. Gemcitabine Cytotoxicity: Interaction of Efflux and Deamination. J Drug Metab Toxicol. 2011 Feb 2; 2(107):1-10. 2180580
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  23. Li F, Fridley BL, Matimba A, Kalari KR, Pelleymounter L, Moon I, Ji Y, Jenkins GD, Batzler A, Wang L, Weinshilboum RM. Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity. Drug Metab Dispos. 2010 Dec; 38(12):2329-38. Epub 2010 Sep 20. 2115587
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  24. Ingle JN, Schaid DJ, Goss PE, Liu M, Mushiroda T, Chapman JA, Kubo M, Jenkins GD, Batzler A, Shepherd L, Pater J, Wang L, Ellis MJ, Stearns V, Rohrer DC, Goetz MP, Pritchard KI, Flockhart DA, Nakamura Y, Weinshilboum RM. Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors. J Clin Oncol. 2010 Nov 1; 28(31):4674-82. Epub 2010 Sep 27. 2116159
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  25. Niu N, Qin Y, Fridley BL, Hou J, Kalari KR, Zhu M, Wu TY, Jenkins GD, Batzler A, Wang L. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. Genome Res. 2010 Nov; 20(11):1482-92. Epub 2010 Oct 05. 2118532
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  26. Wang L, Pelleymounter L, Weinshilboum R, Johnson JA, Hebert JM, Altman RB, Klein TE. Very important pharmacogene summary: thiopurine S-methyltransferase. Pharmacogenet Genomics. 2010 Jun; 20(6):401-5. 2002210
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  27. Wang L, Ellsworth KA, Moon I, Pelleymounter LL, Eckloff BW, Martin YN, Fridley BL, Jenkins GD, Batzler A, Suman VJ, Ravi S, Dixon JM, Miller WR, Wieben ED, Buzdar A, Weinshilboum RM, Ingle JN. Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors. Cancer Res. 2010 Jan 1; 70(1):319-28. 1980548
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  28. Wang L. Pharmacogenomics: a systems approach. Wiley Interdiscip Rev Syst Biol Med. 2010 Jan-Feb; 2(1):3-22. 2114833
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  29. Kalari KR, Hebbring SJ, Chai HS, Li L, Kocher JP, Wang L, Weinshilboum RM. Copy number variation and cytidine analogue cytotoxicity: a genome-wide association approach. BMC Genomics. 2010; 11:357. Epub 2010 Jun 04. 1999310
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  30. Fridley BL, Jenkins G, Schaid DJ, Wang L. A Bayesian hierarchical nonlinear model for assessing the association between genetic variation and drug cytotoxicity. Stat Med. 2009 Sep 20; 28(21):2709-22. 1950966
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  31. Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z, Wang L. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell. 2009 Sep 8; 16(3):259-66. 1960645
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  32. Niu N, Manickam V, Kalari KR, Moon I, Pelleymounter LL, Eckloff BW, Wieben ED, Schaid DJ, Wang L. Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics. J Clin Endocrinol Metab. 2009 Aug; 94(8):3072-84. Epub 2009 May 12. 1942130
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  33. Aksoy P, Zhu MJ, Kalari KR, Moon I, Pelleymounter LL, Eckloff BW, Wieben ED, Yee VC, Weinshilboum RM, Wang L. Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics. Pharmacogenet Genomics. 2009 Aug; 19(8):567-76. 1953752
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  34. Pei H, Li L, Fridley B, Jenkins G, Kalari R, Lingle W, Petersen G, Lou Z, Wang L. FKBP51 acts as a scaffolding protein to regulate Akt phosphorylation. Cancer Cell , In press. 2009. 1945596
  35. Li L, Fridley BL, Kalari K, Jenkins G, Batzler A, Weinshilboum RM, Wang L. Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers. PLoS One. 2009; 4(11):e7765. Epub 2009 Nov 09. 1971332
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  36. Li F, Wang L, Burgess RJ, Weinshilboum RM. Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation. Pharmacogenet Genomics. 2008 Dec; 18(12):1083-94. 1915604
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  37. Wang L, Weinshilboum RM. Pharmacogenomics: candidate gene identification, functional validation and mechanisms. Hum Mol Genet. 2008 Oct 15; 17(R2):R174-9. 1915535
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  38. Li L, Fridley B, Kalari K, Jenkins G, Batzler A, Safgren S, Hildebrandt M, Ames M, Schaid D, Wang L. Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression. Cancer Res. 2008 Sep 1; 68(17):7050-8. 1898788
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  39. Yu Z, Wang L, Hildebrandt MA, Schaid DJ. Testing whether genetic variation explains correlation of quantitative measures of gene expression, and application to genetic network analysis. Stat Med. 2008 Aug 30; 27(19):3847-67. 1854524
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  40. Ji Y, Olson J, Zhang J, Hildebrandt M, Wang L, Ingle J, Fredericksen Z, Sellers T, Miller W, Dixon JM, Brauch H, Eichelbaum M, Justenhoven C, Hamann U, Ko Y, Bruning T, Chang-Claude J, Wang-Gohrke S, Schaid D, Weinshilboum R. Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms. Cancer Res. 2008 Jul 15; 68(14):5997-6005. 1892596
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  41. Wang L, Kumar S, Fridley BL, Kalari KR, Moon I, Pelleymounter LL, Hildebrandt MA, Batzler A, Eckloff BW, Wieben ED, Greipp PR. Proteasome beta subunit pharmacogenomics: gene resequencing and functional genomics. Clin Cancer Res. 2008 Jun 1; 14(11):3503-13. 1894727
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  42. Wang L, Salavaggione E, Pelleymounter L, Eckloff B, Wieben E, Weinshilboum R. Human 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics. J Steroid Biochem Mol Biol. 2007 Oct; 107(1-2):88-99. Epub 2007 Jun 08. 1848883
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  43. Giacomini KM, Brett CM, Altman RB, Benowitz NL, Dolan ME, Flockhart DA, Johnson JA, Hayes DF, Klein T, Krauss RM, Kroetz DL, McLeod HL, Nguyen AT, Ratain MJ, Relling MV, Reus V, Roden DM, Schaefer CA, Shuldiner AR, Skaar T, Tantisira K, Tyndale RF, Wang L The pharmacogenetics research network: from SNP discovery to clinical drug response. Clin Pharmacol Ther. 2007 Mar; 81(3):328-45. 1815332
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  44. Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM. Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies. J Biol Chem. 2006 Mar 17; 281(11):7364-73. Epub 2006 Jan 06. 1754268
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  45. Weinshilboum RM, Wang L. Pharmacogenetics and pharmacogenomics: development, science, and translation. Annu Rev Genomics Hum Genet. 2006; 7:223-45. 1792910
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  46. Wang L, Weinshilboum R. Thiopurine S-methyltransferase (TPMT) pharmacogenetics: a model for clinical and mechanistic pharmacogenetics studies. Oncogene. 2006:1629-38. 1763699
  47. Ji Y, Salavaggione OE, Wang LW, Adjei AA, Eckloff B, Wieben ED, Weinshilboum RM. Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics. J Neurochem. 2005 Dec; 95(6):1766-76. 1736622
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  48. Salavaggione OE, Wang LW, Wiepert M, Yee VC, Weinshilboum RM. Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics. Pharmacogenet Genomics. 2005 Nov; 15(11):801-5. 1736403
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  49. Wang L, Nguyen TV, McLaughlin RW, Sikkink LA, Ramirez-Alvarado M, Weinshilboum RM. Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9394-9. Epub 2005 Jun 20. 1720457
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  50. Weinshilboum R, Wang L. Pharmacogenomics: Bench to bedside. Discov Med. 2005 Feb; 5(25):30-6. 2110393
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  51. Ma CX, Adjei AA, Salavaggione OE, Pelleymounter L, Wang L, Eckloff BW, Schaid D, Wieben ED, Adjei Weinshilboum RM. Human aromatase (CYP19) pharmacogenomics: gene resequencing and functional genomics. Cancer Res. 2005; 65:11071-82. 1763696
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  52. Wang L, Yee VC, Weinshilboum RM. Aggresome formation and pharmacogenetics: sulfotransferase 1A3 as a model system. Biochem Biophys Res Commun. 2004 Dec 10; 325(2):426-33. 1763694
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  53. Weinshilboum R, Wang LW. Pharmacogenomics: Bench to bedside. Nature Reviews. Drug Discovery. 2004 Sep; 3(9):739-48. 1663553
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  54. Wang L, Sullivan W, Toft D, Weinshilboum R. Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation. Pharmacogenetics. 2003 Sep; 13(9):555-64. 1415122
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  55. Salavaggione OE, Kidd L, Prondzinski JL, Szumlanski CL, Pankratz VS, Wang L, Trepanier L, Weinshilboum RM. Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics. Pharmacogenetics. 2002 Dec; 12(9):713-24. 1317835
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  56. Wang L, Thomae B, Eckloff B, Wieben E, Weinshilboum R. Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5 '-flanking region single nucleotide polymorphism (SNP). Biochem Pharmacol. 2002 Aug 15; 64(4):699-710. 1315279
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  57. Wang L, Yan L, McGuire C, Kozak CA, Wang M, Kim UJ, Siciliano M, Weinshilboum RM. Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization. Inflamm Res. 2001 Jun; 50(6):300-8. 1004092
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  58. Holmuhamedov EL, Wang L, Terzic A. ATP-sensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria. J Physiol. 1999 Sep 1; 519 Pt 2:347-60. 1011371
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