Publications

1. Qin B, Gao B, Yu J, Yuan J, Lou Z. Ataxia Telangiectasia-mutated- and Rad3-related Protein Regulates the DNA Damage-induced G2/M Checkpoint through the Aurora A Cofactor Bora Protein. J Biol Chem. 2013 May 31; 288(22):16139-44. Epub 2013 Apr 16. 2317232
   View PubMed
2. Ham H, Guerrier S, Kim J, Schoon RA, Anderson EL, Hamann MJ, Lou Z, Billadeau DD. Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity. J Immunol. 2013 Apr 1; 190(7):3661-9. Epub 2013 Mar 01. 2308224
   View PubMed
3. Pei H, Wu X, Liu T, Yu K, Jelinek DF, Lou Z. The histone methyltransferase MMSET regulates class switch recombination. J Immunol. 2013 Jan 15; 190(2):756-63. Epub 2012 Dec 14. 2290694
   View PubMed
4. Nin V, Escande C, Chini CC, Giri S, Camacho-Pereira J, Matalonga J, Lou Z, Chini EN. Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase. J Biol Chem. 2012 Jul 6; 287(28):23489-501. Epub 2012 May 02. 2242100
   View PubMed
5. Luo K, Zhang H, Wang L, Yuan J, Lou Z. Sumoylation of MDC1 is important for proper DNA damage response. EMBO J. 2012 Jun 29; 31(13):3008-19 Epub 2012 May 25. 2247673
   View PubMed
6. Yuan J, Luo K, Liu T, Lou Z. Regulation of SIRT1 activity by genotoxic stress. Genes Dev. 2012 Apr 15; 26(8):791-6 Epub 2012 Mar 30. 2242630
   View PubMed
7. Qi X, Hou S, Lepp A, Li R, Basir Z, Lou Z, Chen G. Phosphorylation and stabilization of topoisomerase IIalpha protein by p38gamma mitogen-activated protein kinase sensitize breast cancer cells to its poisons. J Biol Chem. 2011 Oct 14; 286(41):35883-90. Epub 2011 Aug 30. 2203783
   View PubMed
8. Luo K, Yuan J, Lou Z. Oligomerization of MDC1 protein is important for proper DNA damage response. J Biol Chem. 2011 Aug 12; 286(32):28192-9 Epub 2011 Jun 24. 2172200
   View PubMed
9. Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev. 2011 May 1; 25(9):959-71. 2167016
   View PubMed
10. Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z. MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature. 2011 Feb 3; 470(7332):124-8. 2147480
    View PubMed
11. Li L, Lou Z, Wang L. The role of FKBP5 in cancer aetiology and chemoresistance. Br J Cancer. 2011 Jan 4; 104(1):19-23. Epub 2010 Nov 30. 2129771
    View PubMed
12. Yuan J, Luo K, Zhang L, Cheville JC, Lou Z. USP10 regulates p53 localization and stability by deubiquitinating p53. Cell. 2010 Feb 5; 140(3):384-96. Epub 2010 Jan 21. 1982482
    View PubMed
13. Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest. 2010 Feb; 120(2):545-58. Epub 2010 Jan 11. 2163859
    View PubMed
14. Kim JE, Chen JJ, Lou Z. p30 DBC is a potential regulator of tumorigenesis. Cell Cycle. 2009 Sep 15; 8(18):2933-6. 1968140
    View PubMed
15. Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W, Petersen G, Lou Z, Wang L. FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell. 2009 Sep 8; 16(3):259-66. 1960645
    View PubMed
16. Yuan J, Pu M, Zhang Z, Lou Z. Histone H3-K56 acetylation is important for genomic stability in mammals. Cell Cycle. 2009 Jun 1; 8(11):1747-53. Epub 2009 Jun 03. 1940735
    View PubMed
17. Yuan J, Minter-Dykhouse K, Lou Z. A c-Myc-SIRT1 feedback loop regulates cell growth and transformation. J Cell Biol. 2009 Apr 20; 185(2):203-11. Epub 2009 Apr 13. 1937453
    View PubMed
18. Clarke MJ, Mulligan EA, Grogan PT, Mladek AC, Carlson BL, Schroeder MA, Curtin NJ, Lou Z, Decker PA, Wu W, Plummer ER, Sarkaria JN. Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines. Mol Cancer Ther. 2009 Feb; 8(2):407-14. Epub 2009 Jan 27. 1920530
    View PubMed
19. Luo K, Yuan J, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol. 2009 Feb; 11(2):204-10. Epub 2008 Dec 21. 1915061
    View PubMed
20. Arneson LN, Segovis CM, Gomez TS, Schoon RA, Dick CJ, Lou Z, Billadeau DD, Leibson PJ. Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity. J Immunol. 2008 Nov 15; 181(10):6995-7001. 1915445
    View PubMed
21. Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11200-5. Epub 2008 Aug 04. 1950052
    View PubMed
22. Minter-Dykhouse K, Ward I, Huen MS, Chen J, Lou Z. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol. 2008 Jun 2; 181(5):727-35. Epub 2008 May 26. 1885159
    View PubMed
23. Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature. 2008 Jan 31; 451(7178):583-6. 1892722
    View PubMed
24. Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG. Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst) 2007 Sep 1; 6(9):1243-54. Epub 2007 Mar 21. 1898579
    View PubMed
25. Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science. 2006 Oct 13; 314(5797):294-7. 1786729
    View PubMed
26. Lou Z, Chen J. Cellular senescence and DNA repair. Exp Cell Res. 2006 Aug 15; 312(14):2641-6. Epub 2006 Jun 20. 1778019
    View PubMed
27. Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell. 2006 Jan 20; 21(2):187-200. 1747080
    View PubMed
28. Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell. 2006 Jan 20; 21(2):201-14. 1747081
    View PubMed
29. Lou Z, Minter-Dykhouse K, Chen J. BRCA1 participates in DNA decatenation. Nat Struct Mol Biol. 2005 Jul; 12(7):589-93. Epub 2005 Jun 19. 1721385
    View PubMed
30. Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J. MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem. 2004 Nov 5; 279(45):46359-62. Epub 2004 Sep 17. 1673800
    View PubMed
31. Lou Z, Chen J. BRCA proteins and DNA damage checkpoints. Front Biosci. 2003 May 1; 8:s718-21. Epub 2003 May 01. 1340503
    View PubMed
32. Lou Z, Chini CC, Minter-Dykhouse K, Chen J. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J Biol Chem. 2003 Apr 18; 278(16):13599-602. Epub 2003 Feb 27. 1341056
    View PubMed
33. Lou Z, Minter-Dykhouse K, Wu X, Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature. 2003 Feb 27; 421(6926):957-61. 1318613
    View PubMed
34. Lou Z, Billadeau DD, Savoy DN, Schoon RA, Leibson PJ. A role for a RhoA/ROCK/LIM-kinase pathway in the regulation of cytotoxic lymphocytes. J Immunol. 2001 Nov 15; 167(10):5749-57. 1007003
    View PubMed
35. Lou Z, Jevremovic D, Billadeau DD, Leibson PJ. A balance between positive and negative signals in cytotoxic lymphocytes regulates the polarization of lipid rafts during the development of cell-mediated killing. J Exp Med. 2000 Jan 17; 191(2):347-54. 127492
    View PubMed