Publications

1. Batton K, Moussa I, Blackshear J, Mergo P, Austin C, Shapiro B. Use of cardiac magnetic resonance imaging for alcohol septal ablation in hypertrophic obstructive cardiomyopathy. Acute Card Care. 2013 May 10. [Epub ahead of print] 2323451
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2. Blackshear JL, Brott TG. Ascertainment of any and all neurologic and myocardial damage in carotid revascularization: the key to optimization? Expert Rev Cardiovasc Ther. 2013 Apr; 11(4):469-84. 2315369
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3. Blackshear JL, Wysokinska EM, Safford RE, Thomas CS, Stark ME, Shapiro BP, Ung S, Johns GS, Chen D. Indexes of von Willebrand factor as biomarkers of aortic stenosis severity (from the Biomarkers of Aortic Stenosis Severity [BASS] study). Am J Cardiol. 2013 Feb 1; 111(3):374-81. Epub 2012 Nov 17. 2285330
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4. Blackshear JL, Safford R, Fredrickson P, Thomas C, Heckman M, Al-Omari M, Kaplan J. Scientific letter: A double-blind, randomised, placebo-controlled, 3-month crossover trial of night-time oxygen therapy in advanced systolic heart failure. Heart. 2012 Oct; 98(19):1468-9. Epub 2012 Aug 3 2288341
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5. Thompson JL 3rd, Schaff HV, Dearani JA, Park SJ, Sundt TM 3rd, Suri RM, Blackshear JL, Daly RC. Risk of recurrent gastrointestinal bleeding after aortic valve replacement in patients with Heyde syndrome. J Thorac Cardiovasc Surg. 2012 Jul; 144(1):112-6. Epub 2011 Aug 23. 2185818
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6. Blackshear JL, Cutlip DE, Roubin GS, Hill MD, Leimgruber PP, Begg RJ, Cohen DJ, Eidt JF, Narins CR, Prineas RJ, Glasser SP, Voeks JH, Brott TG, CREST Investigators. Myocardial infarction after carotid stenting and endarterectomy: results from the carotid revascularization endarterectomy versus stenting trial. Circulation. 2011 Jun 7; 123(22):2571-8. Epub 2011 May 23. 2166834
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7. Blackshear JL, Schaff HV, Ommen SR, Chen D, Nichols WL. Hypertrophic obstructive cardiomyopathy, bleeding history, and acquired von Willebrand syndrome: response to septal myectomy. Mayo Clin Proc. 2011 Mar; 86(3):219-24. 2143784
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8. Brott TG, Hobson RW 2nd, Howard G, Roubin GS, Clark WM, Brooks W, Mackey A, Hill MD, Leimgruber PP, Sheffet AJ, Howard VJ, Moore WS, Voeks JH, Hopkins LN, Cutlip DE, Cohen DJ, Popma JJ, Ferguson RD, Cohen SN, Blackshear JL, Silver FL, Mohr JP, Lal BK, Stenting versus endarterectomy for treatment of carotid-artery stenosis. N Engl J Med. 2010 Jul 1; 363(1):11-23. Epub 2010 May 26. 2105195
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9. Cassidy HD, Cassidy LA, Blackshear JL. Incidental discovery of a patent ductus arteriosus in adults. J Am Board Fam Med. 2009 Mar-Apr; 22(2):214-8. 1929742
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10. Bacani CJ, Maniaci MJ, Blackshear JL. Subacute stent thrombosis in a patient with polycythemia vera. Hosp Physician. 2008 Aug; 44(8):41-5. 1970077
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11. Davidson RM, McNeer JF, Logan L, Higginbotham MB, Anderson J, Blackshear J, Chu A, Hettleman B, McGrew F, Meesse R, O'Connor C, Schneider R, Wagner GS, EXERDUCCS Investigators. A cooperative network of trained sites for the conduct of a complex clinical trial: a new concept in multicenter clinical research. Am Heart J. 2006 Feb; 151(2):451-6. 1968883
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12. Blackshear JL, Kusumoto F. Stroke prevention in atrial fibrillation: warfarin faces its challengers. Curr Cardiol Rep. 2005 Jan; 7(1):16-22. 1703917
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13. Blackshear JL, Safford RE, AFFIRM trial, RACE trial. AFFIRM and RACE trials: implications for the management of atrial fibrillation. Card Electrophysiol Rev. 2003 Dec; 7(4):366-9. 1971675
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14. Joshi SN, Blackshear JL. 66-year-old man with long-standing intermittent chest pain. Mayo Clin Proc. 2003 Nov; 78(11):1405-8. 1422402
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15. Blackshear JL, Johnson WD, Odell JA, Baker VS, Howard M, Pearce L, Stone C, Packer DL, Schaff HV. Thoracoscopic extracardiac obliteration of the left atrial appendage for stroke risk reduction in atrial fibrillation. J Am Coll Cardiol. 2003 Oct 1; 42(7):1249-52. 1416953
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16. Gerber TC, O'Brien PC, Pastor K, Kuzo RS, Blackshear JL, Morin RL. Evaluation of reconstruction windows for multislice computed tomography in quantification of coronary calcium. Invest Radiol. 2003 Feb; 38(2):108-18. 1318222
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17. Gerber TC, Kuzo RS, Lane GE, O'Brien PC, Karstaedt N, Morin RL, Safford RE, Blackshear JL, Pietan JH. Image quality in a standardized algorithm for minimally invasive coronary angiography with multislice spiral computed tomography. J Comput Assist Tomogr. 2003 Jan-Feb; 27(1):62-9. 1318278
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18. Keegan MT, Bondy LR, Blackshear JL, Lanier WL. Hypocalcemia-like electrocardiographic changes after administration of intravenous fosphenytoin. Mayo Clin Proc. 2002 Jun; 77(6):584-6. 1315946
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19. Gerber TC, Kuzo RS, Karstaedt N, Lane GE, Morin RL, Sheedy PF, Safford RE, Blackshear JL, Pietan JH. Current results and new developments of coronary angiography with use of contrast-enhanced computed tomography of the heart. Mayo Clin Proc. 2002 Jan; 77(1):55-71. 1007922
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20. Blackshear JL, Schwartz GL. Step care therapy for hypertension in diabetic patients. Mayo Clin Proc. 2001 Dec; 76(12):1266-74. 1006803
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21. Chugh SS, Blackshear JL, Shen WK, Hammill SC, Gersh BJ. Epidemiology and natural history of atrial fibrillation: clinical implications. J Am Coll Cardiol. 2001 Feb; 37(2):371-8. 1003602
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22. Blackshear JL. Update on antithrombotic therapy in atrial fibrillation. Card Electrophysiol Rev. 2001; 5(2-3):217-221. 1006254
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23. Hines SL, Blackshear JL. 70-year-old woman with chest pain and new diastolic murmur 6 months after coronary artery bypass grafting. Mayo Clin Proc. 2000 Oct; 75(10):1077-80. 1012633
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24. Man-Son-Hing M, Laupacis A, O'Connor AM, Hart RG, Feldman G, Blackshear JL, Anderson DC. Development of a decision aid for patients with atrial fibrillation who are considering antithrombotic therapy. J Gen Intern Med. 2000 Oct; 15(10):723-730. 1013849
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25. Stowers SA, Eisenstein EL, Th Wackers FJ, Berman DS, Blackshear JL, Jones AD Jr, Szymanski TJ Jr, Lam LC, Simons TA, Natale D, Paige KA, Wagner GS. An economic analysis of an aggressive diagnostic strategy with single photon emission computed tomography myocardial perfusion imaging and early exercise stress testing in emergency department patients who present with chest pain but nondiagnostic electrocardiograms: results from a randomized trial. Ann Emerg Med. 2000 Jan; 35(1):17-25. 1012069
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26. Gerber TC, Brady PA, Blackshear JL. Onset and termination of atrial fibrillation. Heart. 2000; 83(5):587. 1345112
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27. Asinger RW, Koehler J, Pearce LA, Zabalgoitia M, Blackshear JL, Fenster PE, Strauss R, Hess D, Pennock GD, Rothbart RM, Halperin JL, for the Stroke Prevention in Atrial Fibrillation Investigators. Pathophysiologic correlates of thromboembolism in nonvalvular atrial fibrillation: II. Dense spontaneous echocardiographic contrast (The Stroke Prevention in Atrial Fibrillation [SPAF-III] study). J Am Soc Echocardiogr. 1999 Dec; 12(12):1088-96. 1345109
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28. Blackshear JL, Pearce LA, Hart RG, Zabalgoitia M, Labovitz A, Asinger RW, Halperin JL. Aortic plaque in atrial fibrillation: prevalence, predictors, and thromboembolic implications. Stroke. 1999 Apr; 30(4):834-40. 1008457
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29. Blackshear JL, Zabalgoitia M, Pennock G, Fenster P, Strauss R, Halperin J, Asinger R, Pearce LA. Warfarin safety and efficacy in patients with thoracic aortic plaque and atrial fibrillation. Am J Cardiol. 1999 Feb 1; 83(3):453-455. 1009904
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30. Blackshear JL, Safford RE. Immediate and long-term prevention of thromboembolism in atrial fibrillation. Cardiac Electrophysiology. 1999; 3:88-92. 1309275
    
31. Seelig MH, Klingler PJ, Oldenburg WA, Blackshear JL. Angiosarcoma of the aorta: report of a case and review of the literature. J Vasc Surg. 1998 Oct; 28(4):732-7. 1020306
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32. Blackshear JL. Valvular and coronary heart disease. When is it time for surgical referral? Postgrad Med. 1998 Jun; 103(6):173-6, 178-80, 185-6. 1018628
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33. Zabalgoitia M, Halperin JL, Pearce LA, Blackshear JL, Asinger RW, Hart RG. Transesophageal echocardiographic correlates of clinical risk of thromboembolism in nonvalvular atrial fibrillation. J Am Coll Cardiol. 1998 Jun; 31(7):1622-1626. 1020045
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34. Atrial Fibrillation Investigators. Echocardiographic predictors of stroke in patients with atrial fibrillation. Archives of Internal Medicine. 1998; 158:1316-1320. 2214036
    
35. The Stroke Prevention in Atrial Fibrillation Investigators Committee on Echocardiography. Transesophageal echocardiographic correlates of thromboembolism in high-risk patients with nonvalvular atrial fibrillation. Ann Intern Med. 1998; 128:639-47. 1755304
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36. Blackshear JL. SPAF III Trial of risk stratification and minimum effective warfarin intensity. Cardiac Electrophysiology Review. 1998; 2:44-8. 1345098
    
37. Blackshear JL. Prevention of thromboembolism in patients with new onset or recently discovered atrial fibrillation. Cardiac Electrophysiological Reviews. 1997; 1:32-9. 1345092
    
38. Blackshear JL. Transition from intravenous to oral diltiazem in atrial fibrillation or flutter. Cardiology Review. 1997; 14:61-4. 1345096
    
39. Blackshear JL, Stambler BS, Strauss WE, Roy D, Dias VC, Beach CL, Ebener MK. Control of heart rate during transition from intravenous of oral diltiazem in fibrillation or flutter. Am J Cardiol. 1996 Dec 1; 78(11):1246-1250. 1026461
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40. The Stroke Prevention in Atrial Fibrillation Investigators. Adjusted-dose warfarin versus low-intensity, fixed-dose warfarin plus aspirin for high-risk patients with atrial fibrillation: Stroke Prevention in Atrial Fibrillation III randomised clinical trial. Lancet. 1996 Sep 7; 348(9028):633-8. 1677554
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41. Stroke Prevention in Atrial Fibrillation Investigators. Transesophageal echocardiography in atrial fibrillation: standards for acquisition and interpretation and assessment of interobserver variability. J Am Soc Echocardiogr. 1996 Jul-Aug; 9(5):556-66. 1755301
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42. Blackshear JL, Safford RE, Pearce LA. F-amplitude, left atrial appendage velocity, and thromboembolic risk in nonrheumatic atrial fibrillation. Clin Cardiol. 1996 Apr; 19(4):309-313. 1025521
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43. Blackshear JL, Baker VS, Holland A, Litin SC, Ahlquist DA, Hart RG, Ellefson R, Koehler J. Fecal hemoglobin excretion in elderly patients with atrial fibrillation: combined aspirin and low-dose warfarin vs conventional warfarin therapy. Arch Intern Med. 1996 Mar 25; 156(6):658-60. 95952
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44. Blackshear JL, Odell JA. Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann Thorac Surg. 1996 Feb; 61(2):755-9. 1024978
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45. Odell JA, Blackshear JL, Davies E, Byrne WJ, Kollmorgen CF, Edwards WD, Orszulak TA. Thoracoscopic obliteration of the left atrial appendage: potential for stroke reduction? Ann Thorac Surg. 1996 Feb; 61(2):565-9. 1024975
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46. Blackshear JL, Kopecky SL, Litin SC, Safford RE, Hammill SC. Management of atrial fibrillation in adults: prevention of thromboembolism and symptomatic treatment. Mayo Clin Proc. 1996 Feb; 71(2):150-60. 95585
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47. Blackshear JL, Miller FA, Loutfi H, Finck SJ, Snyder HE, Agnew RC, Orszulak TA. Valve replacement in aortic stenosis with preoperative mean gradient <50 mmHg: hemodynamic outcome. J Heart Valve Dis. 1996; 5(6):647-655. 98410
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48. Hilton TC, Blackshear JL, Utset B, Kern MJ. Directional coronary atherectomy for coronary artery spasm refractory to medical therapy. Clin Cardiol. 1996; 19:662-4. 1345082
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49. Blackshear JL, Kaplan J, Thompson RC, Safford RE, Atkinson EJ. Nocturnal dyspnea and atrial fibrillation predict Cheyne-Stokes respirations in patients with congestive heart failure. Arch Intern Med. 1995 Jun 26; 155(12):1297-302. 93021
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50. Thompson RC, Mackey DC, Lane GE, Blackshear JL, Shine TS, Ebener MK, Safford RE. Improved detection of silent cardiac ischemia with a 12-lead portable microprocessor-driven real-time electrocardiographic monitor. Mayo Clin Proc. 1995 May; 70(5):434-42. 1022262
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51. Feinberg WM, Blackshear JL, Laupacis A, Kronmal R, Hart RG. Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications. Arch Intern Med. 1995 Mar 13; 155(5):469-73. 1022473
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52. Hilton TC, Keane W, Blackshear JL. Interlobar pulmonary sequestration with nutrient flow from multiple coronary arteries. Am Heart J. 1995; 129:823-6. 1345079
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53. Blackshear JL, Oldenburg WA, Cohen MD. Making the diagnosis when the patient has 'blue toes'. Geriatrics. 1994 Dec; 49(12):37-9, 43-5. 1032666
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54. Loui WS, Blackshear JL, Fredrickson PA, Kaplan J. Obstructive sleep apnea manifesting as suspected angina: report of three cases. Mayo Clin Proc. 1994 Mar; 69(3):244-8. 1032013
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55. Malouf J, Blackshear J, Hilton T, Safford R. The spectrum of thoracic aortic disease. Video J Echocardiogr. 1994; 4:55-61. 1033689
    
56. Malouf JF, Blackshear J, Hilton T, Safford R. Transesophageal echocardiography of thoracic aortic pathology. Video Journal of Echocardiography 55-61 1994; 4:pp. 1137814
    
57. Hilton TC, Menke D, Blackshear JL. Variable effect of anticoagulation in the treatment of severe protruding atherosclerotic aortic debris. Am Heart J. 1994 Jun;127(6):1645-7. 1345069
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58. Flaker GC, McBride R, Blackshear JL, Kronmal RA, Halperin JL, Hart RG. Antiarryhthmic drug therapy and cardiac mortality in atrial fibrillation. Cardiology Board Review. 1994; 10:28-37. 1345077
    
59. Blackshear JL, Pearce LA, Asinger RW, Dittrich HC, Goldman ME, Zabalgoitia M, Rothbart RM, Halperin JL. Mitral regurgitation associated with reduced thromboembolic events in high-risk patients with nonrheumatic atrial fibrillation. Stroke Prevention in Atrial Fibrillation Investigators. Am J Cardiol. 1993 Oct 1; 72(11):840-3. 2218025
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60. Blackshear JL, Jahangir A, Oldenburg WA, Safford RE. Digital embolization from plaque-related thrombus in the thoracic aorta: identification with transesophageal echocardiography and resolution with warfarin therapy. Mayo Clin Proc. 1993 Mar; 68(3):268-72. 82973
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61. Blackshear JL, Safford RE, Kapples EJ. Aortic stasis identified as spontaneous echo contrast in warfarin related atheroembolism. Cardiology in the Elderly. 1993; 1:331-334. 1029511
    
62. Flaker GC, Blackshear JL, McBride R, Kronmal RA, Halperin JL, Hart RG. Antiarrhythmic drug therapy and cardiac mortality in atrial fibrillation. The Stroke Prevention in Atrial Fibrillation Investigators. J Am Coll Cardiol. 1992 Sep; 20(3):527-32. 1985253
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63. Blackshear JL, Kapples EJ, Lane GE, Safford RE. Beat-by-beat aortic valve area measurements indicate constant orifice area in aortic stenosis: analysis of Doppler data with varying RR intervals. J Am Soc Echocardiogr. 1992 Jul-Aug; 5(4):414-20. 1039996
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64. Blackshear JL. Ambulatory monitoring of silent myocardial ischemia: what is its utility? South Med J. 1992 Mar; 85(3):293-8. 1039713
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65. Safford RE, Blackshear JL, Kapples EJ. The spectrum of bioprosthetic valve dysfunction. Video J Echocardiogr. 1992; 1:133-145. 1039994
    
66. Safford RE, Blackshear JL, Kapples EJ. Transesophageal echocardiography: new views of the heart and aorta. Jacksonville Medicine. 1992; 43:21-25. 1039995
    
67. Hilton TC, Blackshear JL. Transesophageal echo: defining the indications. New York State Medical Journal. 1992; 92:5-6. 1040171
    
68. Blackshear JL, Safford RE, Lane GE, Freeman WK, Schaff HV. Unruptured noncoronary sinus of Valsalva aneurysm: preoperative characterization by transesophageal echocardiography. J Am Soc Echocardiogr. 1991 Sep-Oct; 4(5):485-90. 77257
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69. Blackshear JL, Randle HW. Reversibility of blue-gray cutaneous discoloration from amiodarone. Mayo Clin Proc. 1991 Jul; 66(7):721-6. 1037033
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70. Safford RE, Blackshear JL, Kapples EJ. Clinical utility of transesophageal echocardiography. South Med J. 1991 May; 84(5):611-8. 1037480
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71. Blackshear JL, Orlandi C, Hollenberg NK. Constrictive effect of serotonin on visible renal arteries: a pharmacoangiographic study in anesthetized dogs. J Cardiovasc Pharmacol. 1991 Jan; 17(1):68-73. 1037439
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72. Van Woert JH, Thompson RC, Cangemi JR, Metzger PP, Blackshear JL, Fleming CR. Streptokinase therapy for extensive venous thromboses in a patient with severe ulcerative colitis. Mayo Clin Proc. 1990 Aug; 65(8):1144-9. 1034531
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73. Blackshear JL, O'Callaghan WG, Califf RM. Medical approaches to prevention of restenosis after coronary angioplasty. J Am Coll Cardiol. 1987 Apr; 9(4):834-48. 1055684
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74. Blackshear JL, Garnic D, Williams GH, Harrington D, Hollenberg NK. Exaggerated renal vascular response to calcium entry blockade in first degree relatives of essential hypertensives: possible role of intrarenal angiotensin II. Hypertension. 1987; 9:384-389. 1055685
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75. Blackshear JL, Orlandi C, Hollenberg NK. Serotonin and the renal blood supply: role of prostaglandins and the 5HT-2 receptor. Kidney Int. 1986 Sep; 30(3):304-10. 1053046
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76. Orlandi C, Blackshear JL, Hollenberg NK. Specific increase in sensitivity to serotonin of the canine hindlimb collateral arterial tree via the 5-hydroxytryptamine-2 receptor. Microvasc Res. 1986 Jul; 32(1):121-30. 1052863
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77. Orlandi C, Blackshear JL, Hollenberg NK. Serotonin-induced visualization of the popliteal lymph node by angiography. A unique microvascular response to serotonin. Invest Radiol. 1986 Mar; 21(3):201-5. 1052861
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78. Blackshear JL, Orlandi C, Williams GH, Hollenberg NK. The renal response to diltiazem and nifedipine: comparison with nitroprusside. J Cardiovasc Pharmacol. 1986 Jan-Feb; 8(1):37-43. 1052862
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79. Blackshear JL, Napier JS, Davidman M, Stillman MT. Renal complications of nonsteroidal antiinflammatory drugs: identification and monitoring of those at risk. Seminars in Arthritis & Rheumatism. 1985 Feb; 14(3):163-75. 1050074
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80. Blackshear JL, Orlandi C, Garnic JD, Hollenberg NK. Differential large and small vessel responses to serotonin in the dog hindlimb in vivo: role of the 5HT2 receptor. J Cardiovasc Pharmacol. 1985 Jan-Feb; 7(1):42-9. 1050072
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81. Denny DF, Garnic JD, Blackshear JL, Harrington DP, Hollenberg NK. Comparison of the vasodilator response to diltiazem and a standard agent: an angiographic study involving the coronary, mesenteric and femoral vascular beds in the dog. Invest Radiol. 1985; 20:824-829. 1050075
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82. Blackshear JL, Schultz AL, Napier JS, Stuart DD. Thyroxine replacement requirements in hypothyroid patients receiving phenytoin. Ann Intern Med. 1983 Sep; 99(3):341-2. 1117518
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83. Blackshear JL, Napier JS, Davidman M, Stillman MT. NSAID-induced nephrotoxicity: avoidance, detection and treatment. Drug Ther. 1983; 8:47-68. 1117520
    
84. Stillman MT, Napier JS, Blackshear JL. Adverse effects of non-steroidal anti-inflammatory drugs in the kidney. Med Clin North Am. 1983; 68:371-385. 1117521
    
85. Blackshear JL, Davidman M, Stillman MT. Identification of risks for renal insufficiency from non-steroidal anti-inflammatory drugs. Arch Intern Med. 1983; 43:1130-1134. 1117517
    
86. Garnic JD, Schulman G, Boxt LM, Denny DF, Blackshear JL, Harrington DP, Hollenberg NK. Comparison of the response of renal blood supply to a calcium channel blocking agent, diltiazem and acetylcholine. Invest Radiol 18-S5 1983. 1345147
    
87. Blackshear JL, Spielman WS, Knox FG, Romero JC. Dissociation of renin release and renal vasodilation by prostaglandin synthesis inhibitors. Am J Physiol. 1979 Jul; 237(1):F20-4. 39004
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88. Blackshear JL, Edwards BS, Knox FG. Autoregulation of renal blood flow: effects of indomethacin and ureteral pressure. Miner Electrolyte Metab. 1979; 2:130-136. 38565
    
89. Blackshear JL, Wathen RL. Effects of indomethacin on renal blood flow and renin secretory responses to ureteral occlusion in the dog. Miner Electrolyte Metab. 1978; 1:271-278. 1106368