Stephanie L. Safgren

Thesis lab

Martin E. Fernandez-Zapico, M.D.

Research project

My research is focused on the interaction between the GLI1 transcription factor and the SMARCA2 component of the BAF chromatin remodeling complex. GLI1 expression is increased in many tumor types, including pancreatic cancer.

Dr. Fernandez-Zapico's lab wants to determine the mechanism by which GLI1 and SMARCA2 cooperatively regulate gene expression involved in pancreatic cancer initiation and progression. Identification of this regulatory mechanism not only promotes the understanding of pancreatic and other cancers but also identifies key components that can be therapeutically targeted.

Nov. 12, 2015