Sara J. Holditch

What are your research interests?

I study heart failure and polycystic kidney disease, two seemingly unrelated diseases.

Specifically, I am studying BNP, a heart hormone that is involved in homeostasis of, and protection against, cardiorenal syndrome. By looking at the etiology and mechanisms of both diseases, I am working to understand how to use a virus to add back BNP at the right place and time to treat these diseases individually.

Why did you choose Mayo Clinic Graduate School of Biomedical Sciences' Virology and Gene Therapy track?

I came to Mayo because I love viruses, and I love manipulating viruses as vehicles around taking a daily pill to achieve treatments for chronic diseases.

Honors and awards

  • Meritorious Abstract Travel Award, American Society of Gene & Cell Therapy (ASGCT), 2015
  • Travel support recipient, ASN Kidney STARS program, Kidney Week 2014, American Society of Nephrology, 2014
  • 17th Annual Meeting Outstanding Poster Award, ASGCT, 2014
  • $5,000 Small Grant Award, Department of Molecular Medicine, Mayo Clinic, 2013

Presentations

  • Holditch SJ, Cataliotti A, Torres VE, Ikeda Y. Guanylyl cyclase A — Targeted gene therapy ameliorates disease progression in autosomal recessive polycystic kidney disease. Presentation at: American Society of Gene & Cell Therapy Annual Meeting; 2015; New Orleans, La.
  • Holditch SJ, Cataliotti A, Torres VE, Ikeda Y. Guanylyl cyclase A — Targeted gene therapy and renal targeted viral vectors. Presentation at Institute for Molecular Virology Symposium; 2015; Minneapolis, Minn.
  • Holditch SJ, Cataliotti A, Torres VE, Ikeda Y. Guanylyl cyclase A — Targeted gene therapy in autosomal recessive polycystic kidney disease. Presentation at: International Student Symposium; 2015; Kyoto, Japan.

Affiliations

  • American Society of Gene & Cell Therapy
  • American Society of Nephrology
  • American Heart Association

Publications

Nov. 17, 2015