Michael J. Ackerman, M.D., Ph.D.
My research focuses on cardiovascular disease modeling utilizing patient-specific induced pluripotent stem (iPS) cells. Specifically, I am using this model to understand the molecular underpinnings of triadin knockout syndrome.
Triadin is a critical component of a quaternary complex in the sarcoplasmic reticulum that works in conjunction with RyR2, Casq2 and junctophilin to regulate Ca2+ handling within the heart. When triadin is absent, calcium overload occurs, resulting in arrhythmias. Patient-specific iPS cells provide an ideal model to establish therapeutic options for affected individuals.
Nov. 12, 2015