Emma B. Brandt

Thesis lab

Timothy J. Nelson, M.D., Ph.D.

Research project

My research project utilizes induced pluripotent stem cells derived from patients with a congenital heart defect called hypoplastic left heart syndrome (HLHS) and their family members.

Because these induced pluripotent stem cells contain patient-specific genetic information, we can use an in vitro cardiac differentiation method to generate cardiomyocytes and investigate cellular phenotypes that could contribute to this congenital heart defect.

My project focuses on the cell stress response during cardiac development and if an aberrant cell stress response could be a component contributing to HLHS.

Nov. 12, 2015