Brian Lu

What are your research interests?

Diabetes is a major health issue worldwide. Both type 1 and type 2 diabetes are characterized by insulin deficiency and loss of insulin-producing beta cells.

My project uses gene therapy approaches to regenerate lost beta cells as a new way to potentially treat diabetes. Specifically, I'm looking at targeted overexpression of glucokinase in beta cells using a promoter-restricted adeno-associated virus vector.

Normally, glucokinase functions as the "glucose sensor" in beta cells to regulate insulin secretion. We've found that overexpressing glucokinase in beta cells in mice induces beta cells to proliferate. Currently, I'm testing different conditions of glucokinase gene delivery in mice and doing experiments using cell lines to determine the mechanism for glucokinase-mediated beta cell proliferation.

Why did you choose Mayo Clinic Graduate School of Biomedical Sciences' Virology and Gene Therapy track?

I chose Mayo Clinic Graduate School of Biomedical Sciences for its Virology and Gene Therapy track in the Ph.D. Program. Coming out of college, I was interested in virology and more translational research. The Virology and Gene Therapy track offered both basic molecular virology research as well as translational oncolytic vector research. The gene therapy aspect of the Virology and Gene Therapy track is also rather unique, as few other institutions offer such a program.

I felt very welcomed by both the students and the faculty members during interview weekend. Ultimately, I chose Mayo and its Virology and Gene Therapy track because I thought it offered the best Ph.D. training for me.

Posters

  • Lu B, Straus JW, Carreon J. Development of affinity purification systems for isolation and proteomic analysis of proteases from Tetrahymena thermophila. Poster presented at: National Collegiate Research Conference; 2013; Cambridge, Mass.
  • Lu B, Carreon JR, Straus JW. Development of affinity purifications systems for isolation and proteomic analysis of proteases from Tetrahymena thermophila. Poster presented at: American Society for Biochemistry and Molecular Biology Annual Meeting; 2013; Boston, Mass.
  • Lu B, Kurmi K, Tonne JM, Munoz-Gomez M, Jacobus E, Kudva Y, Ikeda Y. Beta-cell targeted gene delivery for enhanced beta-cell proliferation. Poster presented at: Keystone Symposia on Molecular and Cellular Biology: Emerging Concepts and Targets in Islet Biology; 2014; Keystone, Colo.
  • Lu B, Tonne JM, Munoz-Gomez M, Jacobus E, Ikeda Y, Kudva Y. Beta-cell targeted gene delivery for enhanced beta-cell proliferation. Poster presented at: International Student Seminar; 2015; Kyoto, Japan.
  • Lu B, Leber S, Kurmi K, Tonne JM, Sakuma T, Munoz-Gomez M, El Khatib M, Jacobus E, Kudva Y, Ikeda Y. Beta-cell targeted gene delivery for enhanced beta-cell proliferation. Poster presented at: American Diabetes Association 75th Scientific Session; 2015; Boston, Mass.

Presentations

  • Lu B. Beta-cell targeted gene delivery for enhanced beta-cell proliferation. Presentation at: Keystone Symposia on Molecular and Cellular Biology: Emerging Concepts and Targets in Islet Biology; 2014; Keystone, Colo.
  • Lu B. Beta-cell targeted gene delivery for enhanced beta-cell proliferation. Presentation at: 20th Annual Mayo Clinic-Karolinska Institute Scientific Research Meeting; 2014; Rochester, Minn.

Publications

Nov. 17, 2015