Recent Thesis Topics

2011
"Protein Complexes in Ubiquitin Enzymology and Signaling: Translesion
DNA Synthesis and E2-E3 Assembly", Robert C. Benirschke, Ph.D.

"An Anemia-Induced Zebrafish Model of Cardiomyopathy Provides a Unique
Context to Study the Location-Dependent Functions of the Wnt/B-Catenin
Pathway", Tiffany R. Hoage, Ph.D.

"HIV-1 Rev Binding Protein (Hrb) Regulates Efficient Iron Utilization
to Drive Notch-Induced T-cell Leukemogenesis", Shariq S. Khwaja, M.D., Ph.D.

"Hyperactivation of the Sonic Hedgehog Pathway Influences
Cellular Responses to DNA Damage", Jennifer M. Leonard, M.D., Ph.D.

"Oncolytic Virotherapy for Multiple Myeloma", Shruthi Naik, Ph.D.

"Identification and Characterization of Long Non-coding RNAs (lncRNAs)
that have Altered Expression in Cancer", Jessica M. Silva, Ph.D.

"Functional Characterization of the Actin Cytoskeleton Regulator
Formin-like 1 (FMNL1)", Jessica M. Colón Franco, Ph.D.

"Snail1 Contributes to Sonic Hedgehog Pathway Mediated Proliferation
and Transformation of Neural Cells", Leah E. Colvin Wanshura, Ph.D.

"Role of Rtt106 in Replication Coupled Nucleosome Assembly", Ahmed Fazly, Ph.D.

"Endocytic Regulation of Substrate Adhesion in the Steering of Nerve Growth Cones", Jacob H. Hines, Ph.D.

"Biochemical Reaction Kinetics in Dilute and Crowded Solutions:
Predictions of Macroscopic and Mesoscopic Models and Experimental
Observations", Kevin L. Neff, Ph.D.

"Regulation of Focal Adhesions During Cancer Invasion", Yu Wang, Ph.D.

2010
"Protein Complexes in Ubiquitin Enzymology and Signaling: Translesion DNA Synthesis and E2-E3 Assembly", Robert Charles Benirschke, Ph.D.

"Regulation of Transforming Growth Factor-Beta Cell Type-Specific Signaling by Mammalian Target of Rapamycin Complexes", Rod Rahimi, M.D., Ph.D.

"Role of Progranulin in Physiology and Pathology", Jolaine Melissa Twentyman

"Biochemical Reaction Kinetics in Dilute and Crowded Solutions: Predictions of Macroscopic and Mesoscopic Models and Experimental Observations", Kevin L. Neff, Ph.D.

"Characterization of multivesicular body sorting determinants in Saccharomyces cerevisiae", Mariam Sofia Aboian, M.D., Ph.D.

"Regulation of IGF-1 signaling by Alsin", Guo Chen, Ph.D.

2009
"Characterizing the Role of SIAH-Dependent Proteolysis in RAS-mediated Tumorigenesis", Rebecca Leigh Schmidt, Ph.D.

"Multiple Interactions Regulate Substrate Recognition by the Ubiquitin Ligase Rsp5", Jacqueline Rose Eve Lee, Ph.D.

"Selection and Characterization Anti-NF-KB p652 RNA Aptamers In Vitro and In Vivo", Susan E. Wurster, Ph.D.

"Regulation of p68 and p72 RNA Helicases by Post-Translational Modifications", Steven Michael Mooney, Ph.D.

"Light Chain Amyloidosis: Investigating the Dimer Interface for Clues to Amyloidogenicity", Elizabeth M. Baden, Ph.D.

"Androgenic and Anti-Androgenic Regulation of Cellular FLICE-like Inhibitory Protein (FLIP) in Prostate Cancer Cells", Kristin Raclaw Lamont, Ph.D.

"Regulation of AAA-ATPase Vps4 in Multivesicular body sorting pathway", Ishara Fathima Azmi, Ph.D.

"Molecular Genetics of Zebrafish Tcap, A Causative Gene for Muscular Dystrophy and Cardiomyopathy", Ruilin Zhang, Ph.D.

2008
"Molecular Mechanisms of M-CSF-Mediated Osteoclast Survival", Elizabeth W. Bradley, Ph.D.

"Characterization of PCRan1 and PCMei2: Putative Regulators of Meiosis in the Life Cycle of Pneumocystis carinii", Joshua Wayne Burgess, Ph.D.

"Identification of Candidate Tumor Suppressor Genes on Chromosome 19 in Human Gliomas", Kristen Lee Drucker, Ph.D.

"The Role of J Proteins in the Hsp90-Mediated Chaperoning of the Progesterone Receptor", Nela Sofia Moffatt, Ph.D.

"Structural Basis of Epigenetic Recognition, Transcriptional Regulation, and Bypass Replication by Tandem Tudor, PAS, and BRCT domain family members", Joseph Lee, Ph.D.

"Developmental Bioenergetics of Stem Cell Cardiac Differentiation", Susan Chung, M.D., Ph.D.

"Differential Impact of Rin1 on EGFR Signaling and Identification of Novel Rin1 Function", Jin Cui Tomshine, Ph.D.

2007
"Characterization of polycystic kidney disease gene products: Processing and roles in centrosome/ciliary biology", Rachaneekorn Punyashthiti, Ph.D.

"Phosphorylation of Human Topoisomerase I and Its Effect of Enzymatic Activity", Jennifer S. Hackbarth, Ph.D.

"Epithelial Specific Calmodulin-like Protein, a Novel Regulator of Myosin 10 Function", Richard D. Bennett, Ph.D.

"Models of Human Familial Paraganglioma", Emily Helen Smith, Ph.D.

"p53-RNA interactions: in vitro, in yeast, and in human cells", Kasandra Jean-Louis Riley, Ph.D.

"Staphylococcus Lugdunensis Biofilm Formation: Characterization of Antimicrobial Susceptibilites, Phenotypic Responses, and the Role of the ica Locus in Extracellular Matrix Development", Kristi Lynn Frank, Ph.D.

"Identification and Characterization of the Proteolytic Activity of Dihydrolipoamide Dehydrogenase", Ngolela E. Babady, Ph.D.

2006
"Glycosphingolipids and Cholesterol Regulate Caveolar Endocytosis and Secretion via Diverse Signaling Pathways", Jennifer C. Brown, M.D., Ph.D.

"Influence of Inherited Missense Mutations on BRCA2 Function" Daniel Joseph Farrugia, M.D.

"Interactions and Oncogenic Functions of MUC1 in Breast Cancer" Christine Louise Hattrup, Ph.D.

"Characterization of Biochemical Methods for Inducing the Client Binding Activity of the Molecular Chaperone Hsp90", Jonathan Bradley Hoyne, Ph.D.

2005
"Dynamin and Actin-Dependent Processes", James Daniel Orth, Ph.D.

"Biophysical and Functional Characterization of the Co-Chaperone Hsp70/Hsp90 Organizing Protein (HOP)", Patricia Eileen Carrigan, Ph.D.

"Regulation of the Human Telomerase Reverse Transcriptase Gene" Basem Said Goueli, M.D., Ph.D.

"Identification and Characterization of the Gene Mutated in the PCK Rat Model of Polycystic Kidney Disease and Other Members of the Fibrocystin Gene Family" Marie Catherine Hogan, M.D., Ph.D.

"Functional Analysis of LanC1-2 and ECop: Novel Proteins Encoded by Bystander Genes in EGFR Amplicons", Soyeon Park, Ph.D.

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