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Recent Thesis Topics

2013

  • "Functional Characterization of the Serine Protease High-Temperature Requirement A3 (HtrA3) in Lung Cancer," Daniah T. Beleford, Ph.D. (Mentor: Vijayalakshmi Shridhar, Ph.D.)
  • "Genetic Dissection of Ciliopathy Pedigrees with Unusual Disease Presentation or Unresolved Etiology," Katharina Hopp, Ph.D. (Mentor: Peter C. Harris, Ph.D.)
  • "Characterization of the Role of the Meckel Syndrome Protein TMEM67/Meckelin in Cilia Maintenance and Functionality in Animal Models," Amanda C. Leightner, Ph.D. (Mentor: Peter C. Harris, Ph.D.)
  • "Modulation of the AAA+ ATPase Vps4 by Vta1," Andrew P. Norgan, M.D., Ph.D.
  • "Twists and Turns, Bends and Curves: Insights into DNA Deformations," Justin P. Peters, Ph.D. (Mentor: Louis J. Maher III, Ph.D.)
  • "Characterization of the Physiologic Functions of the Proteolytic and Diaphorase Activities of Dihydrolipoamide Dehydrogenase," Rachael A. Vaubel, M.D., Ph.D. (Mentor: Grazia Isaya, M.D., Ph.D.)

2012

  • "Experimental and Computational Approaches to RNA Aptamer Design and Optimization," John P. Bida, Ph.D. (Mentor: Louis J. Maher III, Ph.D.)
  • "Dissection of Molecular and Cellular Functions of a Nucleoporin RanBP2," Masakazu Hamada, Ph.D. (Mentor: Jan van Deursen, Ph.D.)
  • "Serine Hydroxymethyltransferase: Genetic Variation, Functional Characterization and Translational Application," Scott J. Hebbring, Ph.D. (Mentor: Richard Weinshilboum, M.D.)
  • "Striatal Adenosine and Neurotensin Signaling in Alcohol Use Disorders," Moonnoh R. Lee, Ph.D. (Mentor: Doo-Sup Choi, Ph.D.)
  • "The Mechanism of Fibril Formation in Light Chain Amyloidosis," Douglas J. Martin, M.D., Ph.D. (Mentor: Marina Ramirez-Alvarado, Ph.D.)
  • "Molecular Insights into the Structure and Function of Microcephalin," Namit Singh, Ph.D. (Mentor: Georges Mer, Ph.D.)

2011

  • "Protein Complexes in Ubiquitin Enzymology and Signaling: Translesion DNA Synthesis and E2-E3 Assembly", Robert C. Benirschke, Ph.D.
  • "An Anemia-Induced Zebrafish Model of Cardiomyopathy Provides a Unique Context to Study the Location-Dependent Functions of the Wnt/B-Catenin Pathway", Tiffany R. Hoage, Ph.D.
  • "HIV-1 Rev Binding Protein (Hrb) Regulates Efficient Iron Utilization to Drive Notch-Induced T-cell Leukemogenesis", Shariq S. Khwaja, M.D., Ph.D.
  • "Hyperactivation of the Sonic Hedgehog Pathway Influences Cellular Responses to DNA Damage", Jennifer M. Leonard, M.D., Ph.D.
  • "Oncolytic Virotherapy for Multiple Myeloma", Shruthi Naik, Ph.D.
  • "Identification and Characterization of Long Non-coding RNAs (lncRNAs) that have Altered Expression in Cancer", Jessica M. Silva, Ph.D.
  • "Functional Characterization of the Actin Cytoskeleton Regulator Formin-like 1 (FMNL1)", Jessica M. Colón Franco, Ph.D.
  • "Snail1 Contributes to Sonic Hedgehog Pathway Mediated Proliferation and Transformation of Neural Cells", Leah E. Colvin Wanshura, Ph.D.
  • "Role of Rtt106 in Replication Coupled Nucleosome Assembly", Ahmed Fazly, Ph.D.
  • "Endocytic Regulation of Substrate Adhesion in the Steering of Nerve Growth Cones", Jacob H. Hines, Ph.D.
  • "Biochemical Reaction Kinetics in Dilute and Crowded Solutions: Predictions of Macroscopic and Mesoscopic Models and Experimental Observations", Kevin L. Neff, Ph.D.
  • "Regulation of Focal Adhesions During Cancer Invasion", Yu Wang, Ph.D.

2010

  • "Protein Complexes in Ubiquitin Enzymology and Signaling: Translesion DNA Synthesis and E2-E3 Assembly", Robert Charles Benirschke, Ph.D.
  • "Regulation of Transforming Growth Factor-Beta Cell Type-Specific Signaling by Mammalian Target of Rapamycin Complexes", Rod Rahimi, M.D., Ph.D.
  • "Role of Progranulin in Physiology and Pathology", Jolaine Melissa Twentyman
  • "Biochemical Reaction Kinetics in Dilute and Crowded Solutions: Predictions of Macroscopic and Mesoscopic Models and Experimental Observations", Kevin L. Neff, Ph.D.
  • "Characterization of multivesicular body sorting determinants in Saccharomyces cerevisiae", Mariam Sofia Aboian, M.D., Ph.D.
  • "Regulation of IGF-1 signaling by Alsin", Guo Chen, Ph.D.

2009

  • "Characterizing the Role of SIAH-Dependent Proteolysis in RAS-mediated Tumorigenesis", Rebecca Leigh Schmidt, Ph.D.
  • "Multiple Interactions Regulate Substrate Recognition by the Ubiquitin Ligase Rsp5", Jacqueline Rose Eve Lee, Ph.D.
  • "Selection and Characterization Anti-NF-KB p652 RNA Aptamers In Vitro and In Vivo", Susan E. Wurster, Ph.D.
  • "Regulation of p68 and p72 RNA Helicases by Post-Translational Modifications", Steven Michael Mooney, Ph.D.
  • "Light Chain Amyloidosis: Investigating the Dimer Interface for Clues to Amyloidogenicity", Elizabeth M. Baden, Ph.D.
  • "Androgenic and Anti-Androgenic Regulation of Cellular FLICE-like Inhibitory Protein (FLIP) in Prostate Cancer Cells", Kristin Raclaw Lamont, Ph.D.
  • "Regulation of AAA-ATPase Vps4 in Multivesicular body sorting pathway", Ishara Fathima Azmi, Ph.D.
  • "Molecular Genetics of Zebrafish Tcap, A Causative Gene for Muscular Dystrophy and Cardiomyopathy", Ruilin Zhang, Ph.D.

2008

  • "Molecular Mechanisms of M-CSF-Mediated Osteoclast Survival", Elizabeth W. Bradley, Ph.D.
  • "Characterization of PCRan1 and PCMei2: Putative Regulators of Meiosis in the Life Cycle of Pneumocystis carinii", Joshua Wayne Burgess, Ph.D.
  • "Identification of Candidate Tumor Suppressor Genes on Chromosome 19 in Human Gliomas", Kristen Lee Drucker, Ph.D.
  • "The Role of J Proteins in the Hsp90-Mediated Chaperoning of the Progesterone Receptor", Nela Sofia Moffatt, Ph.D.
  • "Structural Basis of Epigenetic Recognition, Transcriptional Regulation, and Bypass Replication by Tandem Tudor, PAS, and BRCT domain family members", Joseph Lee, Ph.D.
  • "Developmental Bioenergetics of Stem Cell Cardiac Differentiation", Susan Chung, M.D., Ph.D.
  • "Differential Impact of Rin1 on EGFR Signaling and Identification of Novel Rin1 Function", Jin Cui Tomshine, Ph.D.
  • Jan 21, 2014
  • ART322512