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The research activities in Rochester are centered in the Guggenheim, Stabile and Medical Sciences buildings. The Siebens Medical Education Building houses classrooms, computer labs, study areas and administrative offices. The Mitchell Student Center offers a state-of-the-art Learning Resource Center, including a library and a computer lab. 

The Plummer Building houses Mayo Clinic's medical library system, one of the largest in the world, containing more than 350,000 bound volumes and 4,300 medical and scientific journal subscriptions. Access to extensive online medical database resources is readily available.

Patient care activity is centered in the Mayo and Gonda buildings. These interconnected buildings, together with Rochester Methodist Hospital, comprise the core of Mayo's clinical facilities in downtown Rochester. Saint Marys Hospital, three blocks west of the downtown campus, and Rochester Methodist Hospital are integral to the education programs, providing essential clinical care experiences for students and trainees.

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