Each of the laboratories in the Division of Laboratory Genetics at Mayo Clinic provides testing for a wide range of genetic disorders. Over recent years, one focus of the Biochemical Genetics Laboratory has been newborn screening. In addition, the Molecular Genetics Laboratory and Cytogenetics Laboratory offer numerous tests in the areas of hematology and oncology. There will be numerous case conferences and many interactions with consultants in other laboratories and clinical departments (e.g. Medical Genetics, Pediatrics, Neurology, Experimental Pathology, Hematology and Hematopathology).

Clinical Training

Case work will involve working closely with board certified clinical biochemical geneticists and genetic counselors. Your experience will include:

  • Collection of appropriate clinical and pedigree information from the referring clinician
  • Review of technical work performed
  • Scoring and interpretation of results
  • Performing risk calculations
  • Generation of the test report
  • Subsequent follow-up with the referring clinician

Didactic Training

Didactic training will be provided by formal lectures, case conferences, seminars and journal reviews. Additionally, enrollment in Mayo Clinic Graduate School of Biomedical Sciences courses may be required, depending upon your previous training and experience.

For certification by the American Board of Medical Genetics (ABMG) in Clinical Molecular Genetics, Clinical Cytogenetics, or Clinical Biochemical Genetics, a general genetics examination together with the specialty examination must be taken. Our fellowship programs provide the required training in all aspects of Medical Genetics (Clinical Genetics, Molecular Genetics, Cytogenetics, Biochemical Genetics and Genetic Counseling). The training program will encompass a broad range of topics and expertise, including:

  • Molecular, cytogenetic and/or biochemical etiology and pathogenesis of human genetic diseases
  • Laboratory diagnosis and carrier detection of a broad range of genetic disorders and malignancies using a range of state-of-the-art molecular techniques
  • Risk calculations, including Bayesian analysis and calculations for linkage analyses
  • Genetic counseling of disorders diagnosed by laboratory methods
  • Technical problems, potential pitfalls and laboratory quality control/assurance procedures
  • See also American Board of Medical Genetics (ABMG).

Practical Laboratory Experience

Each genetics laboratory is fully equipped for diagnostic and research work. You will have ample opportunity for involvement in research projects and/or the development of new clinical tests. In addition, you will review quality control and quality assurance procedures, and participate in preparing the laboratory for certification inspections by on-site reviewers from the College of American Pathologists (CAP) and New York State .

Research Training

Clinical testing at Mayo Clinic benefits from active research and development programs. Developmental activities in the Division of Laboratory Genetics are focused on improving current test strategies and introducing new genetic tests. All approved tests meet rigid validation standards that include a thorough evaluation of methodology and clinical utility.

Our research programs combine the expertise and experience of Mayo Clinic scientists to advance the field of genetics and genetic testing.

Call Frequency

Your call schedule will vary by individual rotation within each fellowship. Mayo Clinic follows the recommendations of the Accreditation Council for Graduate Medical Education.

Teaching Opportunities

In all of Mayo Clinic's genetic fellowships, you will have the opportunity to teach Mayo Clinic School of Medicine students, pathology residents, and visiting students from other medical schools through laboratory bench instruction and formal didactic lectures.


To ensure that you acquire adequate knowledge and develop your technical skills, your performance will be monitored carefully during the course of your fellowship. You will be evaluated formally by your supervising faculty member on a quarterly basis. In addition, you will regularly evaluate the faculty to ensure that your educational needs are being met.