Essentials of Antiretroviral Therapy is a component of the HIV eCurriculum Series, an innovative, evidence-based, online curriculum designed with unique content for health care workers taking care of HIV-infected patients. The program will serve a variety of professionals across the care continuum, providing for a foundation of shared knowledge. It strives to offer relevant, practical, and tailored education through a series of courses with individual topics presented in the form of modules. The HIV eCurriculum Series Ethiopia is supported by the Centers for Disease Control and Prevention, the President’s Emergency Plan for AIDS Relief, and the Federal Ministry of Health Ethiopia. Courses are developed and implemented in collaboration with Ethiopian major medical institutions, Ethiopian Pharmaceutical Association, Ethiopian Medical Association, Ethiopian Nurses Association, and Ethiopian Public Health Association.