This symposium brings together basic science and clinical experts in the field of angiogenesis. During this course, the faculty facilitate the exchange of ideas and science involving basic biology and pathways of angiogenesis and new anti-angiogenic agents that can be used for specific targeting of tumor blood vessels and stroma. Clinician scientists present the results of ongoing clinical trials on anti-angiogenic therapy. Novel genetic and imaging methods to assess tumor vasculature for monitoring the effectiveness of angiogenic response in the pre-clinical and clinical trials are discussed. This symposium assists in establishing strong collaborations among leading national, international and Mayo Clinic experts in the field.